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Ramis Vidal, Manuel Guillermo

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Ramis Vidal, Manuel Guillermo
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Universidad de Murcia. Departamento de Producción Animal
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    Evaluation of a wood-based feed supplement as an alternative to zinc oxide: Effects on growth, antioxidant and inflammatory status, and gut integrity in weaned piglets
    (Elsevier B.V., 2025-07-11) Orengo Femenia, Juan; Serrano, Daniel; Murciano Rodríguez, Francisco; Christine Potthast; Stefan Hirtenlehner; Maria José Carrión-López; Ramis Vidal, Manuel Guillermo; Producción Animal
    From July 2022, the European Union banned therapeutic doses of zinc oxide (ZnO) in animal feed, prompting interest in alternative dietary supplements with antioxidant and anti-inflammatory properties. The study examined the effects of adding a wood-based feed supplement, rich in lignans and phenolic acids, to pre-starter and starter diets on piglet growth performance and intestinal integrity post-weaning. A total of 126 piglets were randomly assigned to three treatments: positive control (PC) and negative control (NC) diets with or without high doses of ZnO in the pre-starter diet (Zn levels exceeding 2500 mg/kg vs. 150 mg/kg), and a diet containing a wood-based supplement (WBS) at a dosage of 1500 mg/kg. Growth parameters were assessed weekly during the post-weaning period. Moreover, blood and fecal samples were collected at 14 days to analyze antioxidant parameters, acute phase proteins, and gene expression related to gut integrity and immune response. No differences in feed conversion ratio were observed among dietary treatments. However, PC and WPS piglets had higher feed intake than those from NC. The growth rate in WPS piglets was intermediate and not different from both control groups. The PC group showed higher relative quantification for IL1β, IFNα, TNFα and occludin than the NC group, whereas piglets fed WBS treatment showed intermediate figures. Overall, the study suggests that dietary inclusion of the wood-based supplement showed promise in promoting increased feed intake and moderate anti-inflammatory activity in weaned piglets, potentially mitigating production losses resulting from the ban on therapeutic levels of ZnO in the early post-weaning period.
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    Differences in weight, hierarchy, and incidence of lameness between two groups of adult pigs derived from assisted reproductive technologies
    (MDPI, 2022-12-17) Ramírez, Lisette L.; Ortin Bustillo, Alba; Ramis, Guillermo; Romar, Raquel; Coy, Pilar; Romero Aguirregomezcorta, Jon; Ramírez, Lisette L.; Ortín Bustillo, Alba; Ramis Vidal, Manuel Guillermo; Romar Andrés, Raquel; Coy Fuster, Pilar; Anatomía y Anatomía Patológica Comparadas ; Facultad de Veterinaria
    The in vitro production (IVP) and subsequent transfer of embryos (ET) to recipient mothers is not yet an established reproductive technology in the pig industry, as it is in cattle. However, that the trade of IVP-cryopreserved pig embryos is expected to start in the next decades. Society and governments are increasingly aware of the repercussions that IVP could have for animal health, welfare, behavior, or food safety, but proven scientific information for this type of animal does not exist, since no colonies of pigs have been created to this end. We created a small one and studied the differences between 16 IVP-derived pigs and 14 pigs derived from artificial insemination (AI), at 3.5 years of age, conceived from the same boar, and housed and fed under the same conditions since they were born. Incidence of lameness, position in the herd hierarchy, weight, adenosine deaminase activity, and hematological and biochemical analytes were compared between the two groups of animals. The results showed that the IVP animals weighed more, occupied higher positions in the herd hierarchy, and had a lower incidence of lameness. Although genetic differences from the maternal line could explain some of these results, it is also possible that the IVP animals developed better adaptative abilities, but more studies with a higher number of animals are necessary to reach consistent conclusions.
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    Open Access
    Oral and Parenteral Vaccination against Escherichia coli in Piglets Results in Different Responses
    (MDPI, 2022-10-22) Ramis Vidal, Manuel Guillermo; Pérez-Esteruelas, Lorena; Gómez-Cabrera, Carolina G.; De Pascual-Monreal, Clara; Gonzalez-Guijarro, Belén; Párraga Ros, Ester; Sánchez-Uribe, Pedro; Claver-Mateos, Miguel; Mendonça-Pascoal, Livia; Martínez-Alarcón, Laura; Anatomía y Anatomía Patológica Comparada
    The available E. coli vaccines involve two main types (inactivated and live non-pathogenic) and two routes of administration (oral and parenteral) but the mechanism by which both vaccines and routes of administration work is not yet fully elucidated. The influence of a parenteral vaccine (PV) and an oral one (OV) was studied by analyzing the gene expression of biomarkers indicating cellular infiltration (calprotectin, CAL), tight junction proteins (occludin OCL, and zonulin ZON) that maintain intestinal paracellular integration and two proinflammatory (IFN- ) and anti-inflammatory (TGF- ) mediator cytokines, as well as histomorphology and IgA production cell density. Differences were observed in CAL, more infiltrated in orally vaccinated animals; OCL also increased in orally vaccinated animals, and higher density of IgA-producing cells in ileum for orally vaccinated groups. Cytokine expression is also different; and there is a lower mRNA for IFN- in the parenteral than in the oral vaccinated animals. Finally, the villus height-to-crypt depth ratio was higher in the orally vaccinated groups. The data collectively show clear and different effects derived from the use of each type of vaccine, route of administration and regimen. The results suggest a more rapid and direct effect of oral vaccination and a state of suppression in the absence of a second oral stimulus by the pathogen.
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