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Serna Duque, John Alberto

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Serna Duque, John Alberto
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Universidad de Murcia. Departamento de Biología Celular e Histología
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    Dataset used for Report of "Proteomic changes induced by hepcidin 1 injection in brain and skin of gilthead seabream (Sparus aurata)"
    (2025) Laura García-Navarro; Serna Duque, John Alberto; Marín Parra, Claudia; M. Ángeles Esteban; Biología Celular e Histología; M. Ángeles Esteban
    The present study investigated the effects of hepcidin 1 (Hamp1) on the proteome of brain and skin of gilthead seabream (Sparus aurata). Hepcidin 1, a host defense peptide with antimicrobial and immunomodulatory functions, was inyected intraperitoneally at a dose of 25 μM. Proteomic analyses of brain and skin samples were performed using HPLC-MS/MS at 4 and 10 days post-injection. Data processing and analysis revealed significant alterations in protein expression profiles in both tissues. In the brain, hepcidin 1 injection upregulated proteins involved in DNA repair, myelin sheath structure, and extracellular matrix remodeling at 4 days, while at 10 days, changes were observed in proteins involved in endoplasmic reticulum calcium channels, Golgi apparatus glycosylation, and cytoskeletal dynamics. Skin samples exhibited increased expression of proteins related to endoplasmic reticulum stress response, cell adhesion, and vesicular trafficking at 4 days. At 10 days, skin proteome alterations indicated a metabolic shift towards enhanced glycolysis, oxidative stress adaptation, and cytoskeletal remodeling. These findings suggest that hepcidin 1 induces tissue-specific and time-dependent proteomic changes in gilthead seabream, potentially modulating immune responses, energy metabolism, and cellular adaptation processes. Further research is needed to elucidate the functional implications of these proteomic alterations and their potential applications in aquaculture health management.
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