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Vicente Soler, Jerónima

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Vicente Soler, Jerónima
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Universidad de Murcia. Departamento de Genética y Microbiología
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    Metabolic control of cytokinesis by glucose cAMP–PKA signaling in fission yeast
    (Elsevier, 2025-09-19) Marín Castillo, Antonio; León Zaragoza, Sergio; Franco Sánchez, Alejandro; Vicente Soler, Jerónima; Núñez Hernández, Andrés; Soto Pino, Teresa; Madrid Mateo, María Isabel; Cansado Vizoso, José; Genética y Microbiología; Facultades de la UMU::Facultad de Biología
    Cytokinesis, the final step of cell division, must be precisely coordinated with the cellular metabolic status, yet the underlying regulatory mechanisms remain poorly understood. Here we show that in Schizosaccharomyces pombe, glucose signaling promotes cytokinesis via the evolutionarily conserved cAMP–PKA signaling pathway. Loss of the Pka1 catalytic subunit delays assembly and constriction of the contractile actomyosin ring (CAR), whereas constitutive PKA activation enhances CAR integrity and accelerates cytokinesis. Mechanistically, Pka1 downregulates the basal activity of the stress-activated MAPK Sty1 under glucose-rich conditions, thereby stabilizing the formin For3 and its nucleated actin cables, which collaborate to regulate CAR dynamics. Remarkably, cAMP–PKA signaling also facilitates cytokinesis through a parallel, actin cable–independent mechanism. Additionally, mitochondrial respiration contributes to cytokinesis in the presence of glucose through a PKA-independent pathway. These findings reveal a multilayered network that links carbon source metabolism to cytoskeletal organization and underscore the importance of tight PKA activity control for robust cell division.
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    Unveiling the diversity, ecology, and biotechnological potential of culturable marine yeasts in Western Mediterranean coastal ecosystems
    (Pensoft Publishers, 2026-05-29) Martínez Rodrigo, Alejandra; Núñez Hernández, Andrés; Franco Sánchez, Alejandro; Madrid Mateo, María Isabel; Vicente Soler, Jerónima; Cansado Vizoso, José; Soto Pino, Teresa; Genética y Microbiología; Facultades de la UMU::Facultad de Biología
    Coastal ecosystems are dynamic environments characterized by strong seasonal variability in physicochemical parameters and biological communities. In the western Mediterranean, the Region of Murcia (southeastern Spain) is characterized by notable biodiversity and ecological heterogeneity, encompassing diverse habitats, including rocky shores, sandy beaches, seagrass meadows, and the Mar Menor, one of Europe’s largest hypersaline lagoons. Within these systems, marine yeasts play critical ecological roles in organic matter recycling and produce metabolites of biotechnological and medical interest. This study presents the first comprehensive survey of culturable marine yeasts from the Mediterranean coast of the Region of Murcia. From seawater and sediment samples, 415 strains were identified via internal transcribed spacer (ITS) and large subunit (LSU) rDNA sequencing, revealing 90 species across 44 genera, including 78 known taxa and 12 potentially novel ones. Most isolates were assigned to the phylum Ascomycota (62%), primarily distributed among the classes Pichiomycetes, Dothideomycetes, Saccharomycetes, and Dipodascomycetes, whereas Basidiomycota accounted for the remaining 38%, mainly comprising the classes Tremellomycetes and Microbotryomycetes. The genera most represented in both seawater and sediment were Rhodotorula and Candida, and approximately 10% of the isolates corresponded to stress-tolerant black yeast-like fungi (Aureobasidium spp., Hortaea werneckii, Exophiala oligosperma, and Zalaria alba), a group notable for its taxonomic novelty and valuable biotechnological traits. Culturable yeast assemblages displayed pronounced spatiotemporal variability, with diversity generally increasing during milder seasons and in areas influenced by anthropogenic activity, suggesting the combined effect of natural gradients and human-driven alterations. Representative strains exhibited broad enzymatic capabilities, producing extracellular cellulases, proteases, xylanases, amylases, chitinases, and pectinases, underscoring their ecological role in organic matter turnover and nutrient cycling. The findings provide novel insights into the taxonomic composition and metabolic potential of marine yeasts recovered from the Mediterranean Sea and set the basis for their future exploitation in industrial and environmental biotechnology.
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    Specific functional features of the cell integrity MAP Kinase pathway in the dimorphic fission yeast Schizosaccharomyces japonicus
    (MDPI, 2021-06-14) Gómez Gil, Elisa; Franco Sánchez, Alejandro; Vázquez Marín, Beatriz; Prieto Ruiz, Francisco; Pérez Díaz, Armando Jesús; Vicente Soler, Jerónima; Madrid Mateo, María Isabel; Soto Pino, Teresa; Cansado Vizoso, José; Genética y Microbiología; Facultades de la UMU::Facultad de Biología
    Mitogen activated protein kinase (MAPK) signaling pathways execute essential functions in eu-karyotic organisms by transducing extracellular stimuli into adaptive cellular responses. In the fis-sion yeast model Schizosaccharomyces pombe the cell integrity pathway (CIP) and its core effector, MAPK Pmk1, play a key role during regulation of cell integrity, cytokinesis, and ionic homeostasis. Schizosaccharomyces japonicus, another fission yeast species, shows remarkable differences with re-spect to S. pombe, including a robust yeast to hyphae dimorphism in response to environmental changes. We show that the CIP MAPK module architecture and its upstream regulators, PKC orthologs Pck1 and Pck2, are conserved in both fission yeast species. However, some of S. pombe’s CIP-related functions, such as cytokinetic control and response to glucose availability, are regulated differently in S. japonicus. Moreover, Pck1 and Pck2 antagonistically regulate S. japonicus hyphal differentiation through fine-tuning of Pmk1 activity. Chimeric MAPK-swapping experiments re-vealed that S. japonicus Pmk1 is fully functional in S. pombe, whereas S. pombe Pmk1 shows a limited ability to execute CIP functions and promote S. japonicus mycelial development. Our findings also suggest that a modified N-lobe domain secondary structure within S. japonicus Pmk1 has a major influence on the CIP signaling features of this evolutionarily diverged fission yeast.2021
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