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Artal Soriano, Pablo

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Artal Soriano, Pablo
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Universidad de Murcia. Departamento de Física
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    Blind deconvolution of second harmonic microscopy images of the living human eye
    (Optica Publishing Group, 2023-04-19) Mugnier, Laurent M.; Martínez Ojeda, Rosa María; Artal Soriano, Pablo; Bueno García, Juan Manuel; Física
    Second harmonic generation (SHG) imaging microscopy of thick biological tissues is affected by the presence of aberrations and scattering within the sample. Moreover, additional problems, such as uncontrolled movements, appear when imaging in-vivo. Deconvolution methods can be used to overcome these limitations under some conditions. In particular, we present here a technique based on a marginal blind deconvolution approach for improving SHG images obtained in vivo in the human eye (cornea and sclera). Different image quality metrics are used to quantify the attained improvement. Collagen fibers in both cornea and sclera are better visualized and their spatial distributions accurately assessed. This might be a useful tool to better discriminate between healthy and pathological tissues, especially those where changes in collagen distribution occur.
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    The role of thermal accumulation on the fabrication of diffraction gratings in ophthalmic PHEMA by ultrashort laser direct writing
    (MDPI, 2020-12-11) Sola Martínez, Daniel; Vázquez de Aldana, Javier R.; Artal Soriano, Pablo; Física
    The fabrication of diffraction gratings by ultrashort direct laser writing in poly-hydroxyethyl-methacrylate (PHEMA) polymers used as soft contact lenses is reported. Diffraction gratings were inscribed by focusing laser radiation 100 µm underneath the surface of the samples. Low- and high-repetition rate Ti:sapphire lasers with 120 fs pulsewidth working at 1 kHz and 80 MHz respectively were used to assess the role of thermal accumulation on microstructural and optical characteristics. Periodic patterns were produced for different values of repetition rate, pulse energy, laser wavelength, distance between tracks, and scanning speed. Compositional and structural modifications of the processed areas were studied by micro-Raman spectroscopy showing that under certain parameters, thermal accumulation may result in local densification. Far-field diffraction patterns were recorded for the produced gratings to assess the refractive index change induced in the processed areas.
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    Improving multiphoton microscopy by combining spherical aberration patterns and variable axicons
    (MDPI, 2021-12-13) Bueno García, Juan Manuel; Hernández, Geovanni; Skorsetz, Martin; Artal Soriano, Pablo; Física
    Multiphoton (MP) microscopy is a well-established method for the non-invasive imaging of biological tissues. However, its optical sectioning capabilities are reduced due to specimen-induced aberrations. Both the manipulation of spherical aberration (SA) and the use of axicons have been reported to be useful techniques to bypass this limitation. We propose the combination of SA patterns and variable axicons to further improve the quality of MP microscopy images. This approach provides enhanced images at different depth locations whose quality is better than those corresponding to the use of SA or axicons separately. Thus, the procedure proposed herein facilitates the visualization of details and increases the depth observable at high resolution.
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