Pons-Fuster López, Eduardo

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Pons-Fuster López, Eduardo

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Pons-Fuster López, Eduardo

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Universidad de Murcia. Departamento de Anatomía Humana y Psicobiología

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Is YouTube a useful tool for oral care in patients with Parkinson's disease?
(Wiley, 2020-07-06) Ruiz Roca, Juan Antonio; Martínez-Izquierdo, Alejandro; Mengual-Pujante, Daniel; Pons-Fuster López, Eduardo; López Jornet, María Pía; Dermatología, Estomatología, Radiología y Medicina Física; Facultad de Medicina
Introduction: To analyze the quality of YouTube videos offering information about oral care in patients with Parkinson’s disease (PD). Background: Regular oral and dental care is essential for good general health and well-being. In this regard, the motor and/or cognitive problems of people with PD can complicate correct daily hygiene. Materials and methods: A systematic review was made of YouTube videos for the terms “Parkinson’s disease,” “dental education,” “oral care,” “dental care,” “oral disease,” “oral status,” and “oral health.” The videos were assessed for content, duration, number of viewings, days since upload, and likes and dislikes. The interaction index and viewing rate were also evaluated. Video quality was rated using a 5-point Likert scale based on the global quality score (GQS). Results: The search identified 620 videos, of which 42 were included in the analysis. The sources of the uploads were universities (n = 15), television channels (n = 8), and other sources (n = 19). Significant differences were recorded according to the source of information in terms of the duration of the videos (P = .021), the number of views (P = .025), viewing rate (P = .028), days since upload (P = .018), likes (P = .048), and dislikes (P = 0.008). Conclusions: GQS is higher for University videos; YouTube videos are an accessible, effective, informative, and educative tool for improving oral quality of life of patients with PD. Relevance to clinical practice: YouTube is increasingly used by patients with chronic disorders, for many reasons, including the desire for a second opinion, the search for support, and a wish to increase personal knowledge of the disease. Likewise, there is a growing interest in the search for information about oral care and coping skills.
Open Access
Oral health status in older people with dementia: a case-control study
(MDPI, 2021-01-27) López Jornet, Pía; Zamora Lavella, Carmen; Tvarijonaviciute, Asta; Pons-Fuster López, Eduardo; Medicina y Cirugía Animal
Dementia is characterized by a range of cognitive defects with impaired activities of daily living that have implications for patient oral health. Objectives. A case-control study was made of the impact of dementia upon oral health. A total of 152 patients were included: 69 with dementia and 83 controls from the region of Murcia (Spain). The Global Deterioration Scale (GDS) was used to classify the patients and an oral exploration was carried out. Odds ratios (ORs) and confidence intervals (CIs) were estimated using regression models. The patients with more severe disease were significantly more likely to have fewer natural teeth (OR 11.00, 95%CI 1.28–23.22; p = 0.001), a higher plaque index (p = 0.001), and a greater bleeding index (p = 0.001) than the control group. These findings suggest that older adults with dementia have deficient oral health. A higher bleeding index increases the risk of deterioration of cognitive function. The oral hygiene and health of older people with dementia need to be improved.
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Notebook “Advancing the uses and applications of saliva as an analytical sample in the One Health context”
(Interdisciplinary Laboratory of Clinical Análysis University of Murcia, 2024) Muñoz Prieto, Alberto; Tvarijonaviciute, Asta; Peres Rubio, Camila; Llamas Amor, Eva; Tecles Vicente, Fernando; Franco Martínez, Lorena; Gonzalez Arostegui, Luis G.; Pardo Marín, Luis; Bernal Gambín, Luis J.; Botía Gonzalez, María; Contreras Aguilar, María Dolores; López Martínez, Maria Jose; Martinez Subiela, Silvia; Ros Lara, Susana; Ceron Madrigal, José Joaquín; Ros Beruezo, Gaspar; Escudero Pastor, Elisa; López Jornet, Pía; García Martínez, Juan D.; Marti Marti, Keren; Yolanda Collado; Pons-Fuster López, Eduardo; Medicina y Cirugía Animal
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YOUTUBE videos on oral care of the organ or hematopoietic stem cell transplant patients
(Springer, 2016-11-22) López Jornet, María Pía; Pons-Fuster López, Eduardo; Ruiz Roca, Juan Antonio; Dermatología, Estomatología, Radiología y Medicina Física; Facultades de la UMU::Facultad de Medicina
Objective Video-sharing websites can be a useful platform for disseminating information. The aim of this study was to evaluate information about the oral health care of the organ transplant and hematopoietic stem cell transplant patients available on YouTube™. Methods The transversal study evaluated the content of YouTube™ videos. The videos were located by entering key search terms in the YouTube™ search engine—oral care/dental management/organ transplant/hematopoietic stem cell transplant patients. The videos were then classified as useful, misleading, or as personal experiences reported by patients. The following information was registered: the source of the video, content, interaction, and overall quality. Results A total of 50 videos were reviewed; 16 (33.14%) were classed as useful, 22 (44%) were misleading, and 12 (24%) reported patients’ personal experiences. Significant differences were found in overall quality (p = 0.012). When interaction variables were analyzed statistically significant differences were found for the following: “I did not like this video” (p ≤ 0.05) and comments (p ≤ 0.05). Conclusions Several videos reviewed information on oral care of organ transplant and hematopoietic stem cell transplant patients but were sometimes difficult to interpret. Nevertheless, YouTube™ is a tool that can help supply information and promote oral health care education among of organ transplant and hematopoietic stem cell transplant patients.
Open Access
Chemosensory Function in Burning Mouth Syndrome a Comparative Cross-Sectional Study
(2021-02-25) López-Jornet, Pia; Collado, Yolanda; Zambudio, Alfonso; Tvarijonaviciute, Asta; Pons-Fuster López, Eduardo; Dermatología, Estomatología, Radiología y Medicina Física
Taste and smell are considered to be functions that contribute to the maintenance of good nutritional status. The present study evaluates taste and smell function in patients with burning mouth syndrome (BMS) versus a control group. A cross-sectional study was made of 36 consecutive patients with BMS and 56 healthy patients. Smell was assessed using the Sniffin’ Sticks test, while taste was evaluated with Taste Strips. Oral quality of life was assessed with the Oral Health Impact Profile-14 (OHIP-14), and the severity of dry mouth with the Thompson Xerostomia Inventory. The patients with BMS had a mean age of 60.4 10.5 years, while the controls had a mean age of 61.3 19 years. No significant differences in smell were recorded between the two groups. In contrast, significant differences in taste function were observed between the patients with BMS and the controls. In the patients with BMS, 44.4% suffered taste alterations compared with the 3.4% healthy controls. Further studies in such patients are needed to allow improved management of the chemosensory problems, mouth dryness, and oral health-related quality of life in BMS.
Open Access
Fitoquímicos como agentes adyuvantes terapéuticos frente al cáncer oral
(Universidad de Murcia, 2018-04-12) Pons-Fuster López, Eduardo; López Jornet, María Pía; Gómez García, Francisco José; Facultad de Medicina
Justificación: El carcinoma oral de las células escamosas (COCE) es el cáncer más común de cabeza y cuello. La extirpación quirúrgica es el tratamiento de referencia, junto a la quimioterapia y radioterapia, en combinación con la cirugía. Pese a los avances conseguidos, estos tratamientos aumentan de manera substancial los efectos adversos. En estudios recientes, se han usado distintos extractos y fitoquímicos para explotar su acción adyuvante terapéutica, con el objetivo de reducir los efectos adversos de los tratamientos convencionales. Objetivo: Búsqueda de agentes noveles como adyuvantes para el tratamiento del cáncer oral y sus complicaciones. Métodos: Realizamos ensayos de migración, viabilidad, ciclo celular y apoptosis sobre la línea de cáncer oral escamoso PE/CA-PJ15 tras el tratamiento con los agentes antirresortivos epigalo-3-catequingalato (EGCG), diosgenina (DG) y ácido zoledrónico (ZA). Evaluamos la efectividad de la combinación del 5-Fluorouracilo (5-FU) con EGCG y radiación (0,2.5 y 5 Gy), mediante ensayos de viabilidad, migración y ciclo celular en las líneas PE/CA-PJ15 y H357 de cáncer oral escamoso. Por último, estudiamos el efecto del ZA y los efectos protectores de la combinación de ZA con EGCG mediante pruebas de viabilidad, mineralización, deposición de colágeno y migración en células con fenotipo de osteoblasto SAOS-2. Resultados: Dosis de 100 μM de DG o ZA redujeron la viabilidad (p<0.01) y estimularon la apoptosis. ZA, DG y EGCG redujeron la migración celular y alteraron el ciclo celular, cada uno en una fase distinta. La combinación de 5-FU+EGCG redujo la viabilidad celular y la migración celular en mayor medida que el 5-FU sólo. La adición de EGCG modificó el ciclo celular aumentando la fase G2/M mientras que 5-FU secuestraba la fase S del ciclo celular. La exposición de las células a 5 Gy de radiación disminuye el efecto de la combinación con EGCG. Por último, dosis micromolares (1 y 5 µM) de ZA redujeron la viabilidad celular (p<0.001), migración (p<0.001) y síntesis de colágeno (p<0.001), mientras que la dosis nanomolar (0.1 µM) no produjo ningún efecto. La adición de EGCG tuvo un efecto protector revirtiendo parcialmente la inhibición producida por ZA, incluso aumentando la mineralización (p<0.001). Conclusiones: DG y ZA fueron capaces de reducir la viabilidad, incrementar la apoptosis, modificar el ciclo y reducir la migración celular, mientras que EGCG fue capaz únicamente de modificar el ciclo celular y reducir la migración, por lo tanto los tres agentes testados presentan un potencial efecto quimioterapéutico en el cáncer oral. La combinación de 5-FU con EGCG redujo la viabilidad, migración y alterar el ciclo celular en mayor medida que el 5-FU sólo, principalmente sin radiación o a 2.5 Gy, ya que el aumento de radiación desvanecía el efecto de EGCG. ZA produce efectos negativos sobre la viabilidad, mineralización, deposición colágeno y migración de los osteoblastos a nivel micromolar. Mientras, la adición de EGCG pudo revertir parte de los efectos inhibitorios del ZA. Por ello, la administración conjunta podría reducir los efectos adversos producidos por el tratamiento. Los resultados obtenidos muestran posibles terapias adyuvantes en el tratamiento del cáncer oral, pero han de ser estudiadas in vivo para poder confirmar estos hallazgos. Background: Oral squamous cell carcinoma (OSCC) is the most frequent head and neck cancer. Surgical excision is the benchmark treatment for OSCC patients, along with chemotherapy and radiotherapy in combination with surgery. Despite the progress made, these treatments considerably enhance adverse effects. In recent studies, different plant extracts and phytochemicals have been used to explore their potential action as adjuvants in cancer therapy, with the purpose of decreasing the adverse effects of conventional treatment. Objectives: to search novel compounds as adjuvants in the treatment of oral cancer and its complications Methods: Cell viability, migration, apoptosis and cell cycle evaluation assays were performed in order to assess the effects of different doses of antiresorptive compounds diosgenin (DG), zoledronic acid (ZA) and epigallocatechin-3-gallate (EGCG) on the PE/CA-PJ15 oral cancer cell line. Cell viability, migration and cell cycle were assayed in H357 and PE/CA-PJ15 oral cancer cell lines treated with 5- Fluorouracil (5-FU) alone or in combination with EGCG and radiation (0, 2.5 and 5 Gy) to evaluate the effectiveness of the combination of 5-FU and EGCG. Lastly, we studied the effect of ZA and the protective effects of the combination of ZA with EGCG on SAOS-2 osteoblast-like cells, assaying cell viability, mineralization, collagen synthesis and migration. Results: 100 μM doses of DG or ZA reduced cell viability (p>0.01), as well as boosting apoptosis. ZA, DG and EGCG decreased cell migration and altered cell cycle progression, each compound in a different phase of the cycle. The combination of EGCG with 5-FU reduced cell viability and migration distance in comparison with control samples and the same dose of 5-FU alone. The addition of EGCG modified the cell cycle, increasing numbers of cells in the G2/M phase, while 5-FU arrested the cell cycle in phase S. Cell exposure to 5 Gy radiation decreased the effects of combining with EGCG. Micromolar (1 and 5 µM) doses of ZA reduced cell viability (p<0.001), mineralization (p<0.001), and collagen synthesis (p<0.001), while nanomolar doses (0.1 µM) did not produce any effect. EGCG application had a protective effect, partly reverting the inhibition produced by ZA and even increasing mineralization (p<0.001). Conclusions: Diosgenin and zoledronic acid were able to decrease viability, boost apoptosis, modify the cell cycle and reduce migration, meanwhile EGCG only modified the cell cycle and decreased migration: therefore, these compounds display potential chemotherapeutic effects on oral cancer. The combination of EGCG and 5-FU reduced cell viability and migration and altered cell cycle to a greater extent than 5-FU alone, mainly without radiation or at 2.5 Gy, as an increase in radiation dose decreased EGCG´s effect. ZA at micromolar doses produced negative effects on osteoblast-like cells at all parameters measured, while at nanomolar levels, ZA only affected cell migration. The addition of EGCG partly reversed the effects produced by ZA, thus the joint application of both could reduce the adverse effects produced by conventional treatment. The results obtained show possible promising adjuvant therapies on the treatment of oral cancer, however, these results must be studied in further depth to be confirmed.
Open Access
Photodynamic Therapy, Photobiomodulation and Acetonide Triamcinolone 0.1% in the Treatment of Oral Lichen Planus: A Randomized Clinical Trial
(MDPI, 2022-12-22) Salinas-Gilabert, Carmen; Gomez Garcia, Francisco; Galera Molero, Fe; Vander Beken, Seppe; Lopez Jornet, Pia; Pons-Fuster López, Eduardo; Dermatología, Estomatología, Radiología y Medicina Física
Objective: To evaluate the efficacy of photodynamic therapy (PDT) and photobiomodulation (PBM) in the treatment of oral lichen planus (OLP) in comparison with the use of topical corticosteroids. Material and methods: Sixty patients with OLP were randomized to three groups: group 1 photodynamic therapy applied once a week for four sessions, with orabase cream; group 2 low-power laser application with orabase cream; and group 3 inactive laser with triamcinolone acetonide 0.1%. Patient pain was evaluated, and the Thongprasom severity score, the Oral Health Impact Profile-14 (OHIP-14), and the Hamilton anxiety and depression scale at one and three months of follow-up. (ClinicalTrials.gov Identifier: NCT05127083). Results: Pain decreased significantly over time in all groups, though the symptoms relapsed over follow-up at one and three months in group 3. The OHIP-14 score improved significantly in groups 1 and 2 (p < 0.05), and this improvement was maintained after three months. Lesion resolution evaluated by the Thongprasom score at one month showed significant differences between groups 1 and 3 (p = 0.032) and between groups 2 and 3 (p = 0.024). Conclusions: Photodynamic therapy and photobiomodulation once a week for four weeks are safe and non-invasive treatment options, with the important advantage of lacking adverse effects. Further studies are needed to confirm it.
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YouTube information about diabetes and oral healthcare
(Springer Nature, 2019-08-08) Pons-Fuster López, Eduardo; Ruiz Roca, Juan Antonio; Tvarijonaviciute, Asta; López Jornet, María Pía; Dermatología, Estomatología, Radiología y Medicina Física
Diabetes mellitus is a chronic disease that is increasing at an alarming rate all over the world. The aim of this study was to assess the quality information available on YouTube on diabetes and oral healthcare. This cross-sectional study made a search in YouTube (https ://www.youtu be.com/). Two reviewers assessed the videos and categorized them into useful, misleading or personal experience, and scored them using a global quality scale (GQS) from 1 to 5 according to their overall quality (1 = poor quality; 5 = excellent quality). The source of each video was also registered, as was user interaction with each video. A total of 97 videos were included for analysis. Of these, 30 (30.9%) contained useful information, 61 (62.9%) contained misleading information, and six (6.2%) recounted personal experiences. Overall quality scores showed statistically significant differences between those containing useful information and those with misleading information and personal experience (p = 0.001). Significant differences in content were also found regarding oral hygiene (p = 0.022), periodontitis (p = 0.002), and infection (p = 0.04). YouTube provides informative videos about oral healthcare for diabetics. The quality of the videos was variable and the videos recorded by dental professionals and Universities showed a higher quality. Further research is needed into oral healthcare for diabetics.
Open Access
Effectiveness of the botulinum toxin for treating sialorrhea in patients with Parkinson’s disease: a systematic review
(MDPI, 2019-03-06) Ruiz Roca, Juan Antonio; Pons-Fuster López, Eduardo; López Jornet, María Pía; Dermatología, Estomatología, Radiología y Medicina Física; Facultades de la UMU::Facultad de Medicina
The main objective was to assess the efficacy of botulinum toxin-based treatment for sialorrhea in adult patients with Parkinson’s disease. The search was performed by using the Medline-PubMed, EMBASE and Cochrane Library databases from January 2000–December 2017, in English/Spanish in patients with Parkinson’s disease and sialorrhea. The methodological quality of trials was carried out by following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria and the Newcastle–Ottawa Scale (NOS). Finally, a total of 21 articles were identified as fulfilling the inclusion criteria. There is no consensus regarding the site of injection of the toxin (single or multiple points), toxin dose or follow-up period. In all cases there was a reduction of sialorrhea. Treatment safety increases with the use of ultrasonography. Effects approximately occur at one week post-injection and for 3–5 months. Botulinum toxin is an effective therapeutic strategy or option in treating sialorrhea in adult patients with Parkinson’s disease. More studies with a better design, larger samples and a longer follow-up period are required to confirm these data.