López Albors, Octavio Miguel

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López Albors, Octavio Miguel

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López Albors, Octavio Miguel

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Anatomía y Anatomía Patológica Comparadas

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Open Access
Museo Anatómico Veterinario de la Universidad de Murcia:Gestión de su información para la planificación,organización, educación y acción cultural
(Murcia: Universidad de Murcia, Servicio de publicaciones, 2000) Granado, J. D.; Chaín Navarro, Celia; Vázquez Autón, José María; Gil Cano, Francisco; Latorre Reviriego, Rafael Manuel; López Albors, Octavio Miguel; Orenes Hernández, Mariano; Ramírez Zarzosa, Gregorio José; Facultad de Veterinaria
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Intestinal histopathological changes in a porcine model of pneumoperitoneum-induced intra-abdominal hypertension
(Springer, 2018-05-17) Párraga Ros, Ester; Correa Martín, Laura; Sánchez‑Margallo, Francisco M.; Candanosa‑Aranda, Irma Eugenia; Malbrain, Manu L. N. G.; Wise, Robert; López Albors, Octavio Miguel; Latorre Reviriego, Rafael Manuel; Castellanos, Gregorio; Anatomía y Anatomía Patológica Comparada
Background Low splanchnic perfusion is an immediate effect of pneumoperitoneum-induced intra-abdominal hypertension (IAH). Anatomical structure results in the intestinal mucosa being the area most sensitive to hypoperfusion. The relationship between intestinal injury and clinical parameters of tissue perfusion [abdominal perfusion pressure (APP), gastric intramucosal pH ( pHi) and lactic acid (Lc)] has not been previously studied. This study aimed to monitorize intestinal pathogenesis through sequential ileal biopsies and to measure APP, pHi, and Lc levels at different pneumoperitoneum-induced intraabdominal pressures (20, 30, and 40 mmHg) to evaluate the potential relationships between them. Materials and methods Fifty pigs were divided into four groups; a control group (C) and three experimental groups with different pneumoperitoneum-induced levels [20 mmHg (G20), 30 mmHg (G30), and 40 mmHg (G40)], that were maintained for 3 and 5 h. APP, pHi, and Lc were measured and ileal biopsies taken laparoscopically every 30 min. The mucosal damage was graded using the standardized Park’s Score and animals were classified as injured (I+) or uninjured (I−). Results Different histopathological lesions were observed in groups G20, G30, and G40 but no damage observed in group C. A 33.3% of animals in G20 and G30 were I+ after 3 h, while 93.3% were injured in G40. After 5 h, histopathological lesions were no longer seen in some animals in G20 and only 10% were I+. Conversely, in G30 I+ pigs increased to 80% while those in G40 remained at 93.3% I+. The I+ animals had significantly lower APP and pHi than those I−. Lc was the clinical parameter that showed the earliest differences, with significantly higher figures in I+ animals. Conclusions The evolution of intestinal injuries from pneumoperitoneum-induced IAH depends on the degree of IAP. These damages may be associated with decreases in APP and pHi, and increases in Lc.
Open Access
The histochemical profiles of fibre types in porcine skeletal muscle
(Murcia : F. Hernández, 2001) Vázquez, J.Mª; Moreno, F.; Gil Cano, Francisco; Latorre Reviriego, Rafael Manuel; López Albors, Octavio Miguel; Ramírez Zarzosa, Gregorio José
Using a variety of histochemical methods -mATPase staining after alkaline and acid preincubations, NADH-TR and a-MGPDH- we have investigated the fibre types in porcine skeletal muscle. The results reveal that four major fibre types -1, IIA, IIB and II*- can be separated histochemically in Longissimus lumborum muscle of Landrace pigs. The histochemical properties of the muscle fibre type 11* are very similar to that of type IIX described in other mammals. The existence of IIX fibres in pig muscle has been recently demonstrated by molecular biology techniques and our results validate the use of histochemistry (mATPase) as an easy methodology to differentiate the three fast myosins (type 11 fibres) in pig muscle.
Open Access
Reproductive fluids, used for the in vitro production of pig embryos, result in healthy offspring and avoid aberrant placental expression of PEG3 and LUM.
(BMC, 2021-02-15) París-Oller, E.; Navarro-Serna, S.; Soriano-Ubeda, C.; Lopes, J.S.; Matás, C.; Ruiz, S.; Cánovas, S.; Coy, P.; Romar, R.; Latorre Reviriego, Rafael Manuel; López Albors, Octavio Miguel; Fisiología; Anatomía y Anatomía Patológica Comparadas
Background: In vitro embryo production (IVP) and embryo transfer (ET) are two very common assisted reproductive technologies (ART) in human and cattle. However, in pig, the combination of either procedures, or even their use separately, is still considered suboptimal due to the low efficiency of IVP plus the difficulty of performing ET in the long and contorted uterus of the sow. In addition, the potential impact of these two ART on the health of the offspring is unknown. We investigated here if the use of a modified IVP system, with natural reproductive fluids (RF) as supplements to the culture media, combined with a minimally invasive surgery to perform ET, affects the output of the own IVP system as well as the reproductive performance of the mother and placental molecular traits. Results: The blastocyst rates obtained by both in vitro systems, conventional (C-IVP) and modified (RF-IVP), were similar. Pregnancy and farrowing rates were also similar. However, when compared to in vivo control (artificial insemination, AI), litter sizes of both IVP groups were lower, while placental efficiency was higher in AI than in RF-IVP. Gene expression studies revealed aberrant expression levels for PEG3 and LUM in placental tissue for C-IVP group when compared to AI, but not for RF-IVP group. Conclusions: The use of reproductive fluids as additives for the culture media in pig IVP does not improve reproductive performance of recipient mothers but could mitigate the impact of artificial procedures in the offspring. Keywords: Assisted reproductive technologies, Embryo transfer, In vitro embryo production, Placenta, Reproductive fluids
Open Access
Anatomía veterinaria: experiencia metodológica en el marco del espacio europeo de educación superior
(Murcia, Universidad de Murcia, Servicio de Publicaciones, 2008) Vázquez Autón, José María; Ayala Florenciano, María Dolores; Gil Cano, Francisco; Latorre Reviriego, Rafael Manuel; López Albors, Octavio Miguel; Martínez Gomariz, Francisco; Ramírez Zarzosa, Gregorio José; Sánchez Collado, Cayetano; Facultad de Veterinaria
Open Access
The heart of the killer whale: description of a plastinated specimen and review of the available literature
(MDPI, 2022-01-31) Latorre Reviriego, Rafael Manuel; Graïc, Jean Marie; Raverty, Stephen A.; Soria Gálvez, Federico; Cozzi, Bruno; López Albors, Octavio Miguel; Anatomía y Anatomía Patológica Comparada
The killer whale (Orcinus orca, Linnaeus, 1958) is the largest extant delphinid. Despite its worldwide distribution in the wild and in dolphinariums, its anatomy remains relatively poorly described. In the present study, we describe the detailed morphology of a plastinated killer whale heart. The gross description of the arteries and veins reaching the organ and its coronary vessels are reported. Additional endoscopy and CT (computed tomography) scanning were performed to provide extensive measurements of its parts. In many aspects, the killer whale heart conformed to other delphinid heart descriptions, including position, relative size and shape and specific features such as extensive papillary muscles, trabecular endocardium and trabecula septomarginalis. These characteristics are representative of the delphinid family, suggesting that its functions and capacities are similar to that of other, smaller, dolphins and help understand the conditions in which these predators exert their remarkable physical performance necessary for their survival.
Open Access
Órganos plastinados: recursos para una propuesta de innovación educativa STEM en Educación Secundaria
(Universidad de Murcia, Servicio de Publicaciones, 2023) Delgado-Ruiz, M.ª Carmen; Bernal-Sánchez, Rocío; Latorre Reviriego, Rafael Manuel; López Albors, Octavio Miguel
Los órganos plastinados son piezas anatómicas reales producidas en un laboratorio, imperecederas, carentes de toxicidad y que pueden usarse en cualquier escenario docente. En este trabajo se expone una experiencia educativa novedosa para el ámbito STEM basada en la utilización de órganos plastinados de origen animal. Se diseñó una propuesta didáctica innovadora para el 3er curso de ESO que fue evaluada en cuatro centros de Educación Secundaria durante un periodo de cuatro semanas. El diseño instruccional de la propuesta se apoyó en métodos activos con manipulación directa de los órganos plastinados y de forma complementaria una serie de recursos digitales en forma de vídeos, materiales para actividades gamificadas, cuestionarios y recursos educativos interactivos. Para evaluar la experiencia se utilizó un método mixto que incluyó una recogida de datos cuantitativos y cualitativos mediante cuestionarios y grupos focales con el profesorado y los estudiantes. Los resultados mostraron un alto índice de satisfacción de todos los agentes educativos implicados en la experiencia. Las principales limitaciones señaladas fueron la falta de tiempo, falta de adecuación al calendario y a la programación didáctica de los centros, la experimentación con solo uno de los segmentos del ámbito STEM y la falta de homogeneidad de las muestras participantes. A pesar de todo ello, se puede concluir que el uso de los órganos plastinados en educación secundaria ofrece amplias posibilidades para promover la innovación en educación STEM, a la vez que garantiza unos elevados índices de satisfacción del profesorado y del estudiantado.
Open Access
Tipos de fibras en el músculo esquelético del toro de lidia (bos taurus ibericus): estudio histoquímico y morfométrico.
(Murcia: Universidad de Murcia, Servicio de Publicaciones, 1997) Vázquez Autón, José María; Moreno Medina, Francisco; Gil Cano, Francisco; Latorre Reviriego, Rafael Manuel; López Albors, Octavio Miguel; Martínez Gomariz, Francisco; Ramírez Zarzosa, Gregorio José; Facultad de Veterinaria
Open Access
Comunicaciones Póster.-Identification of lactadherin in the porcine oviductal secretion
(2020-06-03) Acuña, O.S.; Jara, L.; Soriano-Úbeda, C.; Algarra-Oñate, B.; López Albors, Octavio Miguel; Guillén Martínez, Ascensión; Izquierdo Rico, María José; Avilés Sánchez, Manuel; Moros Nicolás, Carla; Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Biología Celular e Histología; Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Fisiología; Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Anatomía y Anatomía Patológica Comparada
Open Access
The pathophysiological impact of intraabdominal hypertension in pigs
(Public Library of science, 2023-08-28) Wise, Robert; Rodseth, Reitze; Párraga Ros, Ester; Latorre Reviriego, Rafael Manuel; López Albors, Octavio Miguel; Correa-Martın, Laura; Francisco M, Sánchez-Margallo; Irma Candanosa-Aranda, Eugenia; Poelaert, Jan; Castellanos, Gregorio; Malbrain, Manu L. N. G; Anatomía y Anatomía Patológica Comparada
Background Intra-abdominal hypertension and abdominal compartment syndrome are common with clinically significant consequences. We investigated the pathophysiological effects of raised IAP as part of a more extensive exploratory animal study. The study design included both pneumoperitoneum and mechanical intestinal obstruction models. Methods Forty-nine female swine were divided into six groups: a control group (Cr; n = 5), three pneumoperitoneum groups with IAPs of 20mmHg (Pn20; n = 10), 30mmHg (Pn30; n = 10), 40mmHg (Pn40; n = 10), and two mechanical intestinal occlusion groups with IAPs of 20mmHg (MIO20; n = 9) and 30mmHg (MIO30; n = 5). Results There were significant changes (p<0.05) noted in all organ systems, most notably systolic blood pressure (SBP) (p<0.001), cardiac index (CI) (p = 0.003), stroke volume index (SVI) (p<0.001), mean pulmonary airway pressure (MPP) (p<0.001), compliance (p<0.001), pO2 (p = 0.003), bicarbonate (p = 0.041), hemoglobin (p = 0.012), lipase (p = 0.041), total bilirubin (p = 0.041), gastric pH (p<0.001), calculated glomerular filtration rate (GFR) (p<0.001), and urine output (p<0.001). SVV increased progressively as the IAP increased with no obvious changes in intravascular volume status. There were no significant differences between the models regarding their impact on cardiovascular, respiratory, renal and gastrointestinal systems. However, significant differences were noted between the two models at 30mmHg,with MIO30 showing worse metabolic and hematological parameters, and Pn30 and Pn40 showing a more rapid rise in creatinine. Conclusions This study identified and quantified the impact of intra-abdominal hypertension at different pressures on several organ systems and highlighted the significance of even short-lived elevations. Two models of intra-abdominal pressure were used, with a mechanical obstruction model showing more rapid changes in metabolic and haematological changes. These may represent different underlying cellular and vascular pathophysiological processes, but this remains unclear.