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González Cuello, Ana María

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González Cuello, Ana María
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Universidad de Murcia. Departamento de Enfermería
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    7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate
    (The Royal Society Publishing, 2023-03) Herrero Ezquerro, María Trinidad; Yuste Lucas, Juan Luis; Cuenca Bermejo, Lorena; Almela Rojo, Pilar; Arenas-Betancur, L.; De Pablos, V.; González Cuello, Ana María; Del Bel, E.; Navarro Zaragoza, Javier; Fernández Villalba, Emiliano; Anatomía
    Nitric oxide (NO) plays a pivotal role in integrating dopamine transmission in the basal ganglia and has been implicated in the pathogenesis of Parkinson disease (PD). The objective of this study was to ascertain whether the NO synthase inhibitor, 7-nitroindazole (7-NI), is able to reduce L-DOPA induced dyskinesias (LIDs) in a non-human primate model of PD chronically intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Six Parkinsonian macaques were treated daily with L-DOPA for 3–4 months until they developed LIDs. Three animals were then co-treated with a single dose of 7-NI administered 45 min before each L-DOPA treatment. Dyskinetic MPTP-treated monkeys showed a significant decrease in LIDs compared with their scores without 7-NI treatment ( p < 0.05). The anti-Parkinsonian effect of L-DOPA was similar in all three monkeys with and without 7-NI co-treatment. This improvement was significant with respect to the intensity and duration of LIDs while the beneficial effect of L-DOPA treatment was maintained and could represent a promising therapy to improve the quality of life of PDpatients.
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    Open Access
    Identification of predictors of sarcopenia in older adults using machine learning: English Longitudinal Study of Ageing
    (MDPI, 2024-11-12) Pavón Pulido, Nieves; Domínguez, Ligia; Blasco García, Jesús Damián; Veronese, Nicola; Lucas Ochoa, Ana María; Fernández Villalba, Emiliano; González Cuello, Ana María; Barbagallo, Mario; Herrero Ezquerro, María Trinidad; GOING FWD Investigators; Medicina Interna; Facultades de la UMU::Facultad de Medicina
    Background: After its introduction in the ICD-10-CM in 2016, sarcopenia is a condition widely considered to be a medical disease with important consequences for the elderly. Considering its high prevalence in older adults and its detrimental effects on health, it is essential to identify its risk factors to inform targeted interventions. Methods: Taking data from wave 2 of the ELSA, using ML-based methods, this study investigates which factors are significantly associated with sarcopenia. The Minimum Redundancy Maximum Relevance algorithm has been used to allow for an optimal set of features that could predict the dependent variable. Such a feature is the input of a ML-based prediction model, trained and validated to predict the risk of developing or not developing a disease. Results: The presented methods are suitable to identify the risk of acquired sarcopenia. Age and other relevant features related with dementia and musculoskeletal conditions agree with previous knowledge about sarcopenia. The present classifier has an excellent performance since the “true positive rate” is 0.81 and the low “false positive rate” is 0.26. Conclusions: There is a high prevalence of sarcopenia in elderly people, with age and the presence of dementia and musculoskeletal conditions being strong predictors. The new proposed approach paves the path to test the prediction of the incidence of sarcopenia in older adults.202
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    Sexual function and intimate partner violence in middle- aged women: a community-based, dual-focus study in Spain
    (The Menopause Society, 0016-10-16) María M. Martínez- Madrid; González Cuello, Ana María; Arnau Sánchez, José; María M. Martínez Madrid; Enfermería; Ana González - Cuello; José Arnau-Sánchez; Facultades de la UMU::Facultad de Enfermería
    Objective: To evaluate the association between sexual function and intimate partner violence (IPV) among sexually active, middle-aged women in Spain, examining each outcome in separate cross-sectional models. Methods: This cross-sectional study included 451 women (40- 64 y) randomly recruited from primary care settings in southeastern Spain. Participants completed the 6-item Female Sexual Function Index (FSFI-6), the Woman Abuse Screening Tool (WAST), and a general sociodemographic and clinical questionnaire. Factors associated with low sexual function and a positive IPV screen were analyzed using generalized linear models of the Poisson family to estimate adjusted prevalence ratios (aPR). Results: The mean age of participants was 50.09 ± 7.05 years. The prevalence of low sexual function (FSFI-6 score ≤ 19) was 33.7%, and the prevalence of a positive IPV screen (WAST score ≥ 14) was 16.6%. Low sexual function was higher among women with a positive IPV screen compared with those without (77.3% vs. 25.0%, P < 0.001). In the multivariate model, a positive IPV screen was related to a higher prevalence of low sexual function (aPR: 2.57; 95% CI: 2.04-3.25). Conversely, low sexual function was linked to a positive IPV screen (aPR: 4.67; 95% CI: 2.78-7.85). Spanish Roma ethnicity was also associated with IPV (aPR: 3.51; 95% CI: 2.14-5.74). Conclusions: Low sexual function and a positive IPV screen were statistically associated in this community-based sample of middle-aged women. A higher prevalence of IPV was observed among certain ethnic minorities. These associations persisted after adjustment for sociodemographic and clinical factors.
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    Open Access
    Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence
    (MDPI, 2021-12) Herrero Ezquerro, María Trinidad; Laorden Carrasco, María Luisa; Cuenca Bermejo, Lorena; Almela Rojo, Pilar; Navarro Zaragoza, Javier; González Cuello, Ana María; Fernández Villalba, Emiliano; Enfermería
    Dysautonomia is a common non-motor symptom in Parkinson’s disease (PD). Most dysautonomic symptoms appear due to alterations in the peripheral nerves of the autonomic nervous system, including both the sympathetic and parasympathetic nervous systems. The degeneration of sympathetic nerve fibers and neurons leads to cardiovascular dysfunction, which is highly prevalent in PD patients. Cardiac alterations such as orthostatic hypotension, heart rate variability, modifications in cardiogram parameters and baroreflex dysfunction can appear in both the early and late stages of PD, worsening as the disease progresses. In PD patients it is generally found that parasympathetic activity is decreased, while sympathetic activity is increased. This situation gives rise to an imbalance of both tonicities which might, in turn, promote a higher risk of cardiac damage through tachycardia and vasoconstriction. Cardiovascular abnormalities can also appear as a side effect of PD treatment: L-DOPA can decrease blood pressure and aggravate orthostatic hypotension as a result of a negative inotropic effect on the heart. This unwanted side effect limits the therapeutic use of L-DOPA in geriatric patients with PD and can contribute to the number of hospital admissions. Therefore, it is essential to define the cardiac features related to PD for the monitorization of the heart condition in parkinsonian individuals. This information can allow the application of intervention strategies to improve the course of the disease and the proposition of new alternatives for its treatment to eliminate or reverse the motor and non-motor symptoms, especially in geriatric patients.
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