Browsing by Subject "Vascular lesion"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome
    (Murcia : F. Hernández, 2006) Tsujil, M.; Hirata, H.; Yoshida, T.; Imanaka-Yoshida, K.; Morita, A.; Uchida, A.
    Increased intra-carpal-tunnel pressure due to swelling of the flexor tenosynovium is the most probable pathological mechanism of idiopathic carpal tunnel syndrome (CTS). To clarify the role of tenascin-C and PG-M/versican, which have often been found to be involved in tissue remodeling and vascular stenosis in the pathogenesis of CTS, we histologically and biochemically examined the production of extracellular matrix in the flexor tenosynovium from 40 idiopathic CTS patients. Tenascin-C was temporarily expressed in the vessel wall, synovial lining and fibrous tissue, with expression regulated differently in each tissue. Tenascin- C expression by vessels correlated with disease duration and appeared to be involved in vascular lesion pathology. Morphometric analysis showed that tenascin- C expression by small arteries is correlated with PGM/ versican expression in surrounding connective tissue. PG-M/versican was also present at the neointima of severely narrowed vessels. Although tenascin-C expression by synovial lining and connective tissue shows marked regional variation and seems inconsistent, in vitro examination suggested that tenascin-C production by these tissues is regulated in response to mechanical strain on the flexor tenosynovium.
  • Thumbnail Image
    Publication
    Open Access
    Pseudoaneurysm as an unusual complication in bone lengthening
    (Elsevier, ) Martínez Ros, Javier; Molina González, José; Salcedo Cánovas, César; Abellán Rivero, Dolores; Hernández Torres, Alicia; Taboada Martín, Rubén; Fernández Pascual, Clemente; Carrillo García, María; Martínez Ros, Miguel; Puertas García-Sandoval, José Pablo; Medicina
    Abstract One of the risks of distraction osteogenesis-based techniques is the development of vascular complications, such as pseudoaneurysms associated with the osteotomies performed or the fixation elements of the external fixator used in the procedure. Pseudoaneurysm are formed when the tunica adventitia of the artery is injured, resulting in a gradual and persistent blood extravasation into the surrounding tissues that is encapsulated and connected to the arterial lumen. This report describes a rare case of a late-presentation pseudoaneurysm in the anterior tibial artery resulting from a tibial lengthening procedure aimed at addressing a leg length discrepancy in a 57-year-old female with severe peripheral neuropathy resulting from long-standing poorly controlled diabetes mellitus. We describe the diagnostic process, the treatment options and confirm how the shape of the bony callus can be a reliable indicator of this pathology, as has already been described in the literature.