Publication: Involvement of tenascin-C and
PG-M/versican in flexor tenosynovial
pathology of idiopathic carpal tunnel syndrome
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Date
2006
Authors
Tsujil, M. ; Hirata, H. ; Yoshida, T. ; Imanaka-Yoshida, K. ; Morita, A. ; Uchida, A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Increased intra-carpal-tunnel pressure due to
swelling of the flexor tenosynovium is the most probable
pathological mechanism of idiopathic carpal tunnel
syndrome (CTS). To clarify the role of tenascin-C and
PG-M/versican, which have often been found to be
involved in tissue remodeling and vascular stenosis in
the pathogenesis of CTS, we histologically and
biochemically examined the production of extracellular
matrix in the flexor tenosynovium from 40 idiopathic
CTS patients. Tenascin-C was temporarily expressed in
the vessel wall, synovial lining and fibrous tissue, with
expression regulated differently in each tissue. Tenascin-
C expression by vessels correlated with disease duration
and appeared to be involved in vascular lesion
pathology. Morphometric analysis showed that tenascin-
C expression by small arteries is correlated with PGM/
versican expression in surrounding connective tissue.
PG-M/versican was also present at the neointima of
severely narrowed vessels.
Although tenascin-C expression by synovial lining
and connective tissue shows marked regional variation
and seems inconsistent, in vitro examination suggested
that tenascin-C production by these tissues is regulated
in response to mechanical strain on the flexor
tenosynovium.
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