Browsing by Subject "Tooth particles"

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    The use of human sterilized crushed tooth particles compared with BTCP biomaterial and empty defects in bone formation inside critical rabbit calvaria sites
    (MDPI, 2023-05-24) Calvo Guirado, José Luis; Cabo Pastor, Marta Belén; Martínez Martínez, Francisco; Garcés Villalá, Miguel Ángel; Carlos Villafranca, Félix de; García Carrillo, Nuria; Fernández Domínguez, Manuel; Cirugía, Pediatría y Obstetricia y Ginecología
    This study aimed to assess the bone regeneration of critical-size defects in rabbit calvaria filled with freshly crushed extracted teeth, comparing them with BTCP biomaterial and empty sites. Materials and methods: Twenty-one female New Zealand rabbits were used in this study. Two critical-size defects 6 mm in size were created in the skull bone, each with a 3 mm separation between them. Three experimental groups were evaluated: Group A (human sterilized crushed teeth granules alone), Group B (Bioner Bone, Bioner Sitemas Implantológicos), and Group C (unfilled defects). The animals were sacrificed at 4 and 8 weeks. Evaluation of the samples involved histological and histomorphometric analyses with radiographic evaluation. The histological evaluation showed a higher volume reduction in Group A compared with Group B (p < 0.05) and Control. Group A showed the highest values for cortical closure and bone formation around the particles, followed by Group B and Group C (p < 0.05). Within the limitations of this animal study, we can conclude that the use of human tooth particles leads to increased bone formation and reduced connective tissue in critical-size defects in rabbit calvaria when compared to BTCP biomaterial. The calvarial model is a robust base for the evaluation of different biomaterials.