Browsing by Subject "T cell tolerance"
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- PublicationOpen AccessDifferential signaling through the T cell receptor: from biochemistry to transplantation tolerance(Murcia : F. Hernández, 1998) Madrenas, J.; Lazarovits, A.I.Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies. Here. we summarize the evidence supporting a critical role for the CO-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptormediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy. Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance.