Browsing by Subject "Stem cell therapy"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Publication
    Open Access
    Current trends in stem cell therapy for improvement of bone quality
    (F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2014) Yamada, Yoichi; Nakamura, Sayaka; Klein, Ophir D.
    As the average lifespan of humans continues to increase, improvement in the quality of life for elderly people is important. Among the most severe problems during aging are bone loss-associated diseases such as poor fracture healing and osteoporosis. Therapy-induced bone loss such as bisphosphonate-associated osteonecrosis of the jaw also increases in incidence with age. Most of the current treatment strategies are focused on antiresorptive and bone formation pharmacological agents, but it is hard to obtain appropriate bone augmentation and there are concerns regarding their long-term safety without side effects. Therefore, a novel method for improvement of bone quality is required, and stem cells are of great interest as potential therapeutic tools for diseases that remain without clinically effective therapies. In this review, we describe the concept of stem cell-based therapy and evaluate the current progress of cell therapy for the improvement of bone quality. In addition, we report and discuss a new clinical strategy in which improved bone quality was obtained by applying bone-marrow derived MSCs with platelet rich plasma in clinical therapy.
  • Thumbnail Image
    Publication
    Open Access
    Restorative potential of ciliary body cells in a retinal ganglion cell degeneration model
    (Nature Research, 2025-05-03) Fernández-Nogales, Marta; Herrera, Macarena; Herrera, Eloisa ; Lucas Ruiz, Fernando; Valiente Soriano, Francisco Javier; Nadal-Nicolás, Francisco Manuel; Agudo Barriuso, Marta; Lucas Ruiz, Fernando; Oftalmología, Optometría, Otorrinolaringología y Anatomía Patológica; Facultades de la UMU::Facultad de Medicina
    The ciliary body (CB) has been proposed as a niche of neural stem cells because, in vitro, cells from this area are able to form neurospheres, proliferate and differentiate. Here, we explore the potential of CB cells to differentiate and replace degenerated retinal ganglion cells (RGCs) in vivo. CB cells and cells from the subventricular zone (SVZ) were isolated from adult or postnatal C57BL/6Tg(CAG-EGFP) mice, respectively, and intravitreally injected into intact retinas, immediately after optic nerve crush or 45 days after the lesion of adult C57/BL/6 mice. Retinas were analysed in whole mounts or cross sections at different time points. Controls were matched untreated retinas. Neither cell type caused gliosis or toxicity when injected into intact retinas. When CB or SVZ cells were injected right after axotomy, they formed an epimembrane without integrating in the retina. However, when CB cells were administered in retinas depleted of RGCs, they integrated into the ganglion cell layer and expressed RGC and neuronal markers. Although SVZ cells were also able to integrate into RGC depleted retinas they did so more slowly than CB cells. These results shed light in the long-standing question of whether cells in the CB have the potential to transdifferentiate in vivo and point to the CB as a suitable source of cells that could be used in cell-replacement therapies for neurodegenerative diseases of the retina.
  • Thumbnail Image
    Publication
    Open Access
    Treatment and new progress of neonatal hypoxic-ischemic brain damage
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Yang, Lijun; Zhao, Hehua; Cui, Hong
    Neonatal hypoxic ischemia (HI) results in different extents of brain damage, and immature brain tissue is particularly sensitive to the stimulation of HI. Hypoxic-ischemic brain damage (HIBD) is a common and serious nervous system disease in neonates, for both full-term infants and preterm infants, and is one of the main causes of neonatal death. The surviving infants are often associated with cerebral palsy, mental retardation, and other sequelae, which severely affect quality of life. For term infants, hypoxia and ischemia mainly affect gray matter, whereas in preterm infants, the white matter. However, up to now, inadequate standards and specific measures that can be used to treat hypoxic-ischemic brain injury are available. Recently, in addition to supportive therapy and symptomatic treatment, research on the treatment of hypoxic-ischemic brain injury has focused on the following aspects: hypothermia therapy, stem cell therapy, neuroprotective agents, ibuprofen, and combination therapy. In this review, we will summarize the treatment of HIBD and make suggestions for the future treatment direction