Publication: Current trends in stem cell therapy
for improvement of bone quality
Authors
Yamada, Yoichi ; Nakamura, Sayaka ; Klein, Ophir D.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
As the average lifespan of humans continues
to increase, improvement in the quality of life for elderly
people is important. Among the most severe problems
during aging are bone loss-associated diseases such as
poor fracture healing and osteoporosis. Therapy-induced
bone loss such as bisphosphonate-associated
osteonecrosis of the jaw also increases in incidence with
age. Most of the current treatment strategies are focused
on antiresorptive and bone formation pharmacological
agents, but it is hard to obtain appropriate bone
augmentation and there are concerns regarding their
long-term safety without side effects. Therefore, a novel
method for improvement of bone quality is required, and
stem cells are of great interest as potential therapeutic
tools for diseases that remain without clinically effective
therapies. In this review, we describe the concept of stem
cell-based therapy and evaluate the current progress of
cell therapy for the improvement of bone quality. In
addition, we report and discuss a new clinical strategy in
which improved bone quality was obtained by applying
bone-marrow derived MSCs with platelet rich plasma in
clinical therapy.
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Citation
Histology and Histopathology, vol. 29, nº 6, (2014)
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