Browsing by Subject "Sarcomatoid carcinoma"

Now showing 1 - 3 of 3
  • Thumbnail Image
    Publication
    Open Access
    Carcinosarcomas: tumors in transition?
    (F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología, 2015) Somarelli, Jason A.; Boss, Mary-Keara; Epstein, Jonathan I.; Armstrong, Andrew J.; Garcia-Blanco, Mariano A.
    Carcinosarcomas are rare, biphasic tumors that are comprised of carcinomatous and sarcomatous elements. While the exact mechanism by which these two phenotypes arise within a single tumor remains unclear, molecular evidence indicates that the epitheliod and spindle-cell components share a clonal origin. We propose that the biphasic nature of these neoplasms may represent an extreme case of epithelial plasticity, in which an epithelial-like cell undergoes a transition to a more mesenchymal phenotype. The present review will discuss both the histological and molecular biological evidence of the involvement of epithelial plasticity in driving the mixed phenotypes observed in carcinosarcomas.
  • Thumbnail Image
    Publication
    Open Access
    Clinicopathological characteristics and prognosis of Chinese patients with sarcomatoid carcinoma of the bladder
    (F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología, 2013) Guo, Ai T.; Huang, Heng; We, Li X.
    Objectives: The purpose of this study was to retrospectively analyze the clinicopathological features and prognosis of Chinese patients diagnosed with sarcomatoid carcinoma (SC) of the bladder. Methods: 13 patients admitted to the General Hospital of People’s Liberation Army (PLA) between 1999 and 2010 (study group) and 74 Chinese patients diagnosed between 1994 and 2010 and reported in one of two Chinese databases (literature group). Results: The two groups were similar in all demographic and clinical characteristics except depth of tumor invasion. SC of the bladder was most common in older males and most patients had high-grade or latestage disease at diagnosis. The 6-month, 1-year, 2-year, and 5-years survival rates were 78.9%, 42.7%, 28.0%, and 21.0%, respectively. Analysis of the association of demographic and clinical characteristics with prognosis indicated no significant effect of sex, age, lesion location, tumor diameter, tumor type, depth of invasion, type of surgery, gross hematuria, and urinary tract infection. Conclusions: Our results suggest that the pathologic tumor stage was unrelated to prognosis. Early diagnosis and surgical intervention are preferred strategies for improvement of prognosis. The association between clinical stage and survival time requires further analysis.
  • Thumbnail Image
    Publication
    Open Access
    Spindle cell lesions of the urinary bladder
    (Murcia : F. Hernández, 1990) Young, Robert H.
    Spindle cell proliferations of diverse types which vary greatly in their behavior may occur in the urinary bladder. Some of them such as the inflammatory pseudotumor and the postoperative spindle cell nodule are reactive and clinically benign although they may be responsible for significant symptoms. On the other hand, certain other lesions such as sarcomatoid carcinomas are typically highly malignant tumours. The features of the inflammatory pseudotumor and postoperative spindle cell nodule have only recently been defined. The tendency of the former to occur in young patients and the association of the latter with a recent operative procedure are important pieces of clinical information which may prevent their mis-diagnosis. The diagnosis of sarcomatoid carcinoma should always be considered when a malignant spindle cell proliferation is encountered in the urinary bladder. Careful search for minor foci of obvious epithelial differentiation is important in establishing the diagnosis which may also be aided by immunohistochemical staining for epithelial markers. Sarcomatoid carcinoma should be distinguished from the rare transitional cell carcinoma with pseudosarcomatous stroma and from carcinosarcoma. The final lesions briefly reviewed here are mesenchymal tumors both benign and malignant, which generally do not pose the same degree of diagnostic difficulty as non-neoplastic mesenchymal proliferations and sarcomatoid carcinomas.