Browsing by Subject "Postmenopause"

Now showing 1 - 5 of 5
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    Ageing of the human oviduct: lectin histochemistry
    (Murcia : F. Hernández, 2001) Gheri, G.; Noci, I.; Sgambati, E.; Borri, P.; Taddei, G.; Gheri Bryk, S.
    The aim of the present research was to investigate the changes of the sugar residues in the oviduct in the course of ageing in postmenopausal women vs normally menstruating women, by means of lectin histochemistry. Twenty asymptomatic postmenopausal women (48- 83 years old) were recruited among patients who underwent a vaginal hysterectomy. Eight normally menstruating women were recruited as controls. Fragments of Fallopian tubes (pars ampullaris) were fixed in 10% formalin and routinely processed. The sections were labelled with HRP-lectins (PNA, SBA, DBA, WGA, Con A, LTA, UEAI). Some sections were pre-treated with neuraminidase prior to staining with HRP-lectins. Among the postmenopausal patients, our histochemical data showed that there was no difference in the localization and distribution of sugar residues of glycoconjugates as detected by various HRP-lectins. Moreover, our results demonstrated that the oviductal epithelium is characterized by apical reactivity in both ciliated and non-ciliated cells. In the course of ageing, the ciliated cells changed their morphology from bathyprismatic to large and rounded shape. ConA lectin reacted intensely with such highly degenerating ciliated cells and could be considered a marker of these cells. The degenerating ciliated cells are also characterized by the absence of sialic acid. In comparison with the sugar residues present in the control group, the oviductal epithelium of postmenopausal women is characterized by the loss of reactivity with DBA, WGA and ConA. Moreover, PNA reactive material was present at the free border of the ciliated and non-ciliated cells. The latter findings were statistically confirmed and could be considered strictly related to the ageing process.
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    Dataset for the article: Metabolomic profiling of urinary phenolic compounds in postmenopausal women after consumption of dark chocolate, green tea, and fruit juice
    (2025-09-18) Rocío González-Barrio; Rocío González-Barrio; Tecnología de los Alimentos, Nutrición y Bromatología; Rocío González-Barrio; Facultades de la UMU
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    Effect of Bioptron Light Therapy on post-menopausal low back pain: A randomized controlled study
    (Universidad de Murcia. Servicio de Publicaciones, 2024) Elemam Ahmed, Mohamed Abdelbaset; Mohamed Awad, Mohamed Ahmed; Abdel Aziz Atta Allah, A Abdel Hamidbdel Hamid; Mustafa Saleh, Marwa Shafiek; Rashad Aboelmagd, Shreen
    Women's bodies undergo numerous changes throughout the post-menopausal period, many of which result in uncomfortable symptoms, including skeletal problems such as low back pain (LBP). The aim of this study was to evaluate the impact of Bioptron Light Therapy (BLT) on post-menopausal LBP in women. This study employed a pretest-posttest randomized experimental trial design. Forty post-menopausal women with LBP, aged 50 to 60 years, were randomized into two groups (study and control group). The control group (Group A, n=20) received abdominal and back isometric exercises only, whereas the study group (Group B, n=20) received BLT in addition to the same isometric exercises, three sessions per week for six weeks. Pain severity using the Visual Analogue Scale (VAS), Pain Pressure Threshold (PPT) using a pressure algometer, and functional disability using the Modified Oswestry Disability Questionnaire (MODQ) were measured for all patients in both groups before and after the treatment program. The Statistical Package of Social Sciences (SPSS) (version 19) was used for data analysis. Based on the results of our study, PPT significantly increased in both groups after treatment (p = 0.0001), with the study group showing a greater increase than the control group (p = 0.001). Pain intensity decreased significantly in both groups (p = 0.0001), with a statistically significant difference favoring the study group (p = 0.0001). MODQ scores also significantly decreased in both groups (p = 0.0001), again favoring the study group (p = 0.0001). BLT can be included as a valuable, effective, and non-invasive method for decreasing pain and improving function for women with post-menopausal LBP.
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    Evaluation of morphology, apoptosis, and cell proliferation of the uterus in postmenopausal women
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2025) Ratajczak, Weronika; Łazowska, Malwina; Laszczyńska, Maria; Rył, Aleksandra; Lubkowska, Anna; Zimny, Małgorzta; Kram, Andrzej; Sipak, Olimpia
    Background. The aim of this study was to evaluate the morphology (atrophy and fibrosis), apopto-sis, and cell proliferation in the uterine wall. The research material came from postmenopausal women who had undergone hysterectomy due to uterine myomas or prolapse of the reproductive organ and were not taking menopausal hormone therapy (MTH). Material and Methods. The collected material was divided into three groups. Group I (n=18) con-sisted of uterine sections taken 1 to 5 years after the last menstruation, Group II (n=17) 6 to 10 years after the last menstruation, and Group III (n=15) over 11 years after the last menstruation. To assess morphology and fibrosis, the uterine sections were subjected to hematoxylin and eosin (HE) staining and to Mallory's staining. In addition, we performed a histochemical examination to identify apopto-sis in endometrial and myometrial cells using the TUNEL method. An immunohistochemical analysis of endometrial and myometrial cells was also performed to detect the location of the proliferating cell nuclear antigen (PCNA). Results. Differences in apoptosis were only found in the myometrium between Group I and Group III, and were strongest in Group I myometrial cells, and weakest in Group III. Neither the endome-trium nor the myometrium showed statistically significant differences in the overall percentage of PCNA(+) cells between groups. Conclusion. Morphological changes in the endometrial and myometrial layers of postmenopausal uteri increased with time since the last menstruation.
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    Human postmenopausal ovary - hormonally inactive fibrous connective tissue or more
    (Murcia : F. Hernández, 2008) Laszczynska, M.; Brodowska, A.; Starczewski, A.; Masiuk, M.; Brodowski, J.
    The ovary undergoes several changes after the menopause. In this period, the main structural changes in both the cortex and medulla were observed. In the cortex, they included: 1) reduction of its thickness; 2) epithelial inclusions forming cysts; 3) blurring the line between medulla and cortex; 4) reduction of follicles number; 5) tendency to fragmentation of corpora albicantia; 6) surface epithelium invaginations. Whereas the changes in the medulla included: 1) fibrosis and scars in stroma; 2) architectonical changes in blood vessels with hyalinization of walls and constriction of lumen. The loss of follicles and several changes in the ovary are due to apoptotic processes. Despite age related atrophic changes, the postmenopausal ovary is not devoid of hormonal activity. Our results are coherent with the reports of other researchers, and reveal that postmenopausal ovary produces trace quantities of steroid hormones, mainly androgens, and confirm the presence of steroid receptors and activity of main enzymes involved in steroidogenesis process.