Browsing by Subject "Porcine bone"

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    Biological response to porcine xenograft implants: an experimental study in rabbits
    (Lippincott Williams & Wilkins, 2012-04) Calvo Guirado, José Luis; Gómez Moreno, Gerardo; Guardia, Javier; Ortiz Ruiz, Antonio José; Piatelli, Adriano; Barone, Antonio; Martínez González, José María; Meseguer Olmo, Luis; López Marí, Laura; Barona Dorado, Cristina; Dermatología, Estomatología, Radiología y Medicina Física
    Purpose: The aim of this study was to evaluate the effect of a new porcine biomaterial and collagen paste in 20 New Zealand rabbits. Materials and Methods: Forty implants using a porcine xenograft made up of 80% corticocancellous collagenated bone particles of ≤300 μm in size were placed in the proximal metaphyseal area of both tibiae. Four periods of time were formed: 1h, 5, 8, and 15 months. After implantation, an anteroposterior and lateral radiological study was carried out. Samples were sectioned at 5 μm and stained using hematoxylin-eosin, Masson's trichromic, and Gordon-Switt reticulin stains. Results: These results confirmed the biocompatibility of this porcine biomaterial-collagen paste; only a few, occasional macrophages and scattered lymphocytes were observed. No fibrosis was observed between the implants and the bone. Moreover, the material was osteoconductive acting as a “scaffold” for bone cells, and there was a progressive increase in bone growth in and around the implants. Conclusion: This new porcine biomaterial-collagen paste seemed to be biocompatible, bioresorbable, and osteoconductive.