Browsing by Subject "Natural products"

Now showing 1 - 3 of 3
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    Enantiospecific synthesis of antifungal dasyscyphin E from cupressic acid
    (Elsevier, 2017-11-16) Fernandez, Antonio; Boulifa, Ettahir; Jimenez, Fermin; Mahdjour, Soumicha; Ahmed I., Mansour; Chahboun, Rachid; Alvarez-manzaneda, Enrique; Química Orgánica
    The first synthesis of the sesquiterpene quinol dasyscyphin E has been achieved starting from cupressic acid. Key steps of the synthetic sequence are the oxidative degradation of the diterpene side chain to give a methylketone, the diastereoselective a-methylation of a protected ketoaldehyde, the subsequent intramolecular aldol condensation and the further Diels-Alder cycloaddition of a dienol ester.
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    Histopathological alterations in mice under sub-acute treatment with Hintonia latiflora methanolic stem bark extract
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Flores Jiménez, Nancy G.; Rojas Lemus, Marcela; Fortoul, Teresa I.; Zepeda Rodríguez, Armando; López Camacho, Perla Y.; Anacleto Santos, Jhony; Malagón Gutiérrez, Filiberto; Basurto Islas, Gustavo; Rivera Fernández, Norma
    The indiscriminate use of herbal products is increasingly growing worldwide; nonetheless consumers are not warned about the potential health risks that these products may cause. Hintonia latiflora (Hl) is a tree native to the American continent belonging to the Rubiaceae family and its stem bark is empirically used mainly to treat diabetes and malaria; supplements containing Hl are sold in America and Europe without medical prescription, thus scientific information regarding its toxicity as a consequence of a regular consumption is needed. In the present study, the histopathological effect of 200 and 1000 mg/kg of Hl methanolic stem bark extract (HlMeOHe) was evaluated in the small bowel, liver, pancreas, kidneys and brain of CD-1 male mice after oral sub-acute treatment for 28 days. No histopathological alterations were observed in the brain of the treated animals; however, mice presented diarrhea from day 2 of treatment with both doses. No histological changes were observed in the tissues collected from the animals treated with 200 mg/kg, except for the liver that depicted periportal hepatitis. Animals treated with the higher dose showed in the liver sections hydropic degeneration, hepatitis and necrosis small bowel sections showed dilated mucosal vessels, kidney sections depicted tubular necrosis and in pancreas sections, hydropic degeneration of the pancreatic islets was observed. In conclusion, HlMeOHe damaged the liver with an oral dose of 200 mg/kg, and at 1000 mg/kg injured the kidneys and pancreas of the CD1 male mice.
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    Industrial use of pepper (Capsicum annum L.) derived products : technological benefits and biological advantages
    (Elsevier, 2018-09-10) Baenas, Nieves; Belovic, Miona M.; Ilic, Nebojsa M.; Moreno, Diego A.; García-Vigueraº, Cristina; Tecnología de Alimentos, Nutrición y Bromatología
    In pursuit of new bioactive compounds and natural ingredients for agro-food, cosmetic and pharma industrial uses, as replacements for synthetic compounds and also for the valorisation of crop plant’s by-products, the recovery of pepper (Capsicum annum, L.) bioactive compounds represent an interesting strategy to develop new products for the industry. Besides, being used as a condiment, providing characteristic of pungency, colour and flavour, the new pepper-derived ingredients may be used in preservation and extension of lifespan of industrial products, as well as additives or technological ingredients with antioxidant and antimicrobial activities. Moreover, the applicability of the new products in pharmaceutical formulas for treating certain inflammatory and pain-related conditions is also a possibility, since pepper fruits mainly contain capsaicinoids, carotenoids, phenolic compounds, vitamin C and A, and minerals, such as iron and calcium, with health-promoting potential. Further studies on appropriate extraction protocols, stability, safety and bioactivity are key to provide with novel and promising pepper ingredients for foods, cosmetics, and pharmaceutical applications.