Browsing by Subject "Multicenter study"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    Effects of mindfulness-based cognitive therapy for chronic pain: a multicenter study
    (MDPI, 2021-06-29) Pardos Gascón, Estela María; Narambuena, Lucas; Leal Costa, César; Ramos Morcillo, Antonio Jesús; Ruzafa Martínez, María; Hofstadt Román, Carlos Javier van der; Enfermería
    The prevalence of chronic pain in Spain is 15%. The objective of this study was to evaluate the efficacy of mindfulness-based cognitive therapy on patients with chronic pain. A quasiexperimental design of repeated measures pre- and post-test (N = 57) was carried out at three hospitals from the province of Alicante. Self-reported assessment measurements of pain intensity, anxiety-depression symptoms, perception of health status, interference of pain on sleep, self-efficacy in pain, acceptance, and mindfulness attitude were included. The T-test indicates significant differences in intensity of present pain, mental quality of life, and depression (medium effect sizes), as well as in self-efficacy: total score, symptom management and pain control (medium effect sizes), sleep disturbances and quantity of sleep (large effect sizes). MBCT is effective in reducing many symptoms in patients with chronic pain, although its maintenance needs to be further investigated.
  • Thumbnail Image
    Publication
    Open Access
    Histological and immunohistochemical soft-tissue response to cylindrical and concave abutments: multicenter randomized clinical trial
    (Wiley, 2024-08-26) Camacho Alonso, Fabio; Bernabeu Mira, Juan Carlos; Mercado Díaz, Ana María; Pérez Sayans, Mario; Pérez Jardón, Alba; Somoza Martín, José Manuel; Montero, Javier; Gómez Polo, Cristina; Quispe López, Norberto; Peñarrocha Oltra, David; Buendía Marín, Antonio Julián; Sánchez Campillo, Joaquín; Dermatología, Estomatología, Radiología y Medicina Física
    Background:This study aimed to analyze the influence of concave andcylindrical abutments on peri-implant soft tissue. Dimensions, collagen fiberorientation, and immunohistochemical data were assessed.Methods:A multicenter, split-mouth, double-blind randomized clinical trialwas conducted. Two groups were analyzed: cylindrical abutments and concaveabutments. After a 12-week healing period, peri-implant soft tissue samples werecollected, processed, and evaluated for dimensions, collagen fiber orientation,and immunohistochemical data. Inflammatory infiltration and vascularizationwere assessed, and the abutment surfaces were analyzed using scanning elec-tron microscopy. The statistical analysis was performed using the SPSS version20.0 statistical package.Results:A total of 74 samples in 37 patients were evaluated. Histologicalevaluation of peri-implant soft tissue dimensions revealed significant differ-encesbetweenconcaveandcylindricalabutments.Concaveabutmentsexhibitedgreater total height (concave: 3.57±0.28 – cylindrical: 2.95±0.27) and bar-rier epithelium extension (concave: 2.46±0.17 – cylindrical: 1.89±0.21)(p<0.05),whilethesupracrestalconnectivetissueextension(concave:1.11±0.17– cylindrical: 1.03±0.16) was slightly greater (p>0.05). Collagen fiber ori-entation favored concave abutments (23.76±5.86), with significantly moretransverse/perpendicular fibers than for cylindrical abutments (15.68±4.57).The immunohistochemical analysis evidenced greater inflammatory and vascu-lar intensity in the lower portion for both abutments, though concave abutmentsshowed lower overall intensity (concave: 1.05±0.78 – cylindrical: 1.97±0.68) (p<0.05). The abutment surface analysis demonstrated a higher percentage oftissue remnants on concave abutments (42.47±1.32; 45.12±3.03) (p<0.05).Conclusions:Within the limitations of this study, concave abutments pre-sented significantly greater peri-implant tissue height, linked to an extendedbarrier epithelium, versus cylindrical abutments in thick tissue phenotype.This enhanced soft tissue sealing, favoring a greater percentage of transverselyoriented collagen fibers. The concave design reduced chronic inflammatoryexudation with T and B cells, thus minimizing the risk of chronic inflammation.