Browsing by Subject "Microbiota-gut-brain axis"

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    A meta-analysis of gut microbiota in children with autism
    (Springer, 2021) Andreo Martínez, Pedro; Rubio Aparicio, María; Sánchez Meca, Julio; Veas, Alejandro; Martínez González, Agustín Ernesto; Química Agrícola, Geología y Edafología
    Previous studies have reported dysbiosis in the gut microbiota (GM) of children with autism spectrum disorders (ASD), which may be a determining factor on child development through the microbiota-gut-brain axis. However, it is not clear if there is a specific group of dysbiotic bacteria in ASD. The aim of this study was to carry out a meta-analysis on the studies that analyze GM in children with ASD. 18 studies fulfilled our selection criteria. Our results showed a lower relative abundance of Streptococcus (SMD+ = − 0.999; 95% CI − 1.549, − 0.449) and Bifidobacterium genera (SMD+ = − 0.513; 95% CI − 0.953, − 0.073) in children with ASD. Overall, the Bifidobacterium genera is involved. However, differences found between studies are attributed to factors such as reporting bias.