Browsing by Subject "Liver, Ultrastructure"
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- PublicationOpen AccessUltrastructural localization of Cu, Zn-SOD in hepatocytes of patients with various liver diseases(Murcia : F. Hernández, 1989) Saito, Takafumi; Shinzawa, Haruhide; Togashi, Hitoshi; Wakabayashi, Hiroto; Ukai, Katsuaki; Takahashi, Tsuneo; Ishikawa, Makoto; Dobashi, Michio; Imai, YutakaThe ultrastructural localization of copper, zinc-superoxide dismutase (Cu, Zn-SOD) in the liver of patients with acute hepatitis, chronic hepatitis, liver cirrhosis and alcoholic fatty liver was studied by means of the indirect immunoperoxidase technique. In hepatocytes Cu, Zn-SOD was found to be localized in perinuclear cisternae, rough endoplasmic reticulum (rER), vesicles and Golgi apparatus. The Cu, Zn-SOD was also detected around the lipid droplets in hepatocytes as well as on the cytoplasmic membrane in cases of liver cirrhosis. These findings suggest that Cu, Zn-SOD is produced in the rER in hepatocytes and protects the cells from cellular injury caused by superoxide anion radical in various disorders of the liver.