Publication: Ultrastructural localization of Cu, Zn-SOD in
hepatocytes of patients with various liver diseases
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Date
1989
Authors
Saito, Takafumi ; Shinzawa, Haruhide ; Togashi, Hitoshi ; Wakabayashi, Hiroto ; Ukai, Katsuaki ; Takahashi, Tsuneo ; Ishikawa, Makoto ; Dobashi, Michio ; Imai, Yutaka
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ultrastructural localization of copper,
zinc-superoxide dismutase (Cu, Zn-SOD) in the liver of
patients with acute hepatitis, chronic hepatitis, liver
cirrhosis and alcoholic fatty liver was studied by means of
the indirect immunoperoxidase technique. In hepatocytes
Cu, Zn-SOD was found to be localized in perinuclear
cisternae, rough endoplasmic reticulum (rER), vesicles
and Golgi apparatus. The Cu, Zn-SOD was also detected
around the lipid droplets in hepatocytes as well as on the
cytoplasmic membrane in cases of liver cirrhosis.
These findings suggest that Cu, Zn-SOD is produced
in the rER in hepatocytes and protects the cells from
cellular injury caused by superoxide anion radical in
various disorders of the liver.
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