Browsing by Subject "Leprosy"

Now showing 1 - 6 of 6
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    ADAMTS4 is expressed in different cells and tissues in leprosy skin lesions: A potential biomarker and therapeutic target for leprosy and its reactional phenomena
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2026) Rafael Dantas Soares; Igor Bueno Garrido; Natália Silveira Virgili; Luciana Raquel Vincenzi Fachin; Patricia Sammarco Rosa; Ana Paula Fávaro Trombone; Andrea de Faria Fernandes Belone; Cleverson Teixeira Soares; Biología Celular e Histología
    Introduction. A disintegrin and metallo-proteinase with thrombospondin motifs-4 (ADAMTS4), a metalloproteinase involved in extracellular matrix (ECM) degradation, is implicated in several pathological conditions. This study evaluated ADAMTS4 in leprosy skin lesions. Methods. In total, 519 skin samples were selected, including 20 healthy controls (HC) and 499 samples with leprosy skin lesions. Leprosy lesions were divided into tuberculoid range “T” (n=95), lepromatous range “L” (n=115), type 1 reaction (n=120), type 2 reaction (n=128), and lesions in regression (n=41). Following standardization with an anti-ADAMTS4 marker, all samples were subjected to immunohistochemistry (IHC). Marker expression in cells or tissues with moderate or intense staining intensity (2+ or 3+) was considered positive, and the absence of or weak expression (0 or 1+) was considered negative. Results. ADAMTS4 was expressed in several cells involved in the inflammatory processes of leprosy, particularly macrophages and fibroblasts, and in different skin tissues affected by leprosy lesions. Marker expression was remarkable in different tissues affected by leprosy lesions compared with the control group. Conclusion. ADAMTS4 expression in different leprosy lesions and their reaction phenomena suggest its contribution to disease progression and reactive inflammatory amplification, indicating ADAMTS4 as a potential biomarker and therapeutic target in leprosy.
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    El aspecto físico y las repercusiones en la calidad de vida y autonomía de personas mayores afectadas por la lepra
    (Universidad de Murcia, 2017) da Silva Viana, Lucian; Freire de Aguiar, Maria Isis; Freire de Vasconcelos, Patricia; Cardoso de Aquino, Dorlene Maria
    La lepra, junto con el envejecimiento trae cambios físicos que afectan a la dependencia y a la autonomía. El objetivo fue evaluar el aspecto físico y el impacto en la calidad de vida y la independencia de las personas mayores afectadas por la lepra. Estudio descriptivo con un enfoque cuantitativo, con 60 ancianos en dos centros de rehabilitación en Sao Luis - MA. Se utilizó el dominio físico de la WHOQOL - bref y Facetas "Habilidades sensoriales" y "Autonomía" del WHOQOL -.OLD, de la Organización Mundial de la Salud. Se observó problemas con el dolor / malestar (31,3%), fatiga (21 3%) y el sueño / descanso (23,3%), actuando en la incapacidad para el transporte (23,3%), la realización de actividades cotidianas (16,6%) y el trabajo (33,3%), así como relacionados con la dependencia de medicamentos / tratamientos (56,6%). La calidad de vida se alteró por la pérdida sensorial (33,3%), así como la capacidad de realizar actividades (28,3%) e interactuar con personas (23,3%). En cuanto a la autonomía, la mayoría de las personas mayores se sintieron libres para tomar decisiones (53,3%) y se sintieron respetadas por tomarlas (55,0%), aunque afirmaron no hacer todo lo que quisieran (38,3 %). Por lo tanto, se concluye que la enfermedad ante el proceso de la senescencia y / o proceso de la senilidad puede haber contribuido negativamente sobre los aspectos físicos y calidad de vida de las personas mayores.
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    Epidermal Langerhans cells in infectious diseases
    (Murcia : F. Hernández, 1989) Tapia, F.J.; Cáceres-Dittmar, G.; Acuña, Lourdes; Mosca, Walter
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    Immunohistochemical assessment of cell populations in leprosy-spectrum lesions and reactional forms
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2017) Fachin, Luciana Raquel Vincenzi; Soares, Cleverson Teixeira; Belone, Andrea de Faria Fernandes; Trombone, Ana Paula Favaro; Rosa, Patrícia Sammarco; Guidella, Cássio Cesar; Franco, Marcello Fabiano
    In situ immunophenotyping of leprosy lesions can improve our understanding of the biology of inflammatory cells during the immune response to Mycobacterium leprae antigens. In the present study, biopsies from 10 healthy controls and 70 leprosy patients were selected, 10 for each of the following conditions: clinical tuberculoid (TT), borderline tuberculoid (BT), borderline borderline (BB), borderline lepromatous (BL), lepromatous (LL), reversal reaction (R1), and erythema nodosum leprosum (R2). Qualitative and quantitative immunohistochemical analyses were performed to detect CD3, CD4, CD8, FoxP3, CD20, CD138, CD1a, CD57, CD15, CD117, CD68, and CD163. In addition, histochemistry was employed to identify eosinophils. The amount of CD3+ and CD4+ T cells was higher in TT than in LL patients. CD8+ T cells were predominant in T lymphocyte infiltrations in the basal layer of the epidermis. The number of FoxP3+ cells was similar among different forms of the disease, but was higher in BL and LL than in R2 individuals. CD20+ lymphocytes were most abundant in TT samples, while CD138+ plasma cells displayed no detectable differences. Epithelioid macrophages from the center of TT and R1 granulomas exhibited the M1 phenotype (CD68+CD163- ), whereas those in LL granulomas showed the M2 phenotype (CD68+CD163+). There was a gradual decrease in the amount of CD1a+ cells from the TT towards the LL form of the disease. A significant increase in the number of neutrophils was observed only in R2 samples. All the cells investigated, except eosinophils, participated in the immunopathogenesis of leprosy.
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    Lepra. Impacto psicosocial
    (Murcia : Servicio de Publicaciones de la Universidad de Murcia, 2012) Blanco Córdova, C.A.; Cangas García, T.
    Las enfermedades infecciosas se han convertido en un importante problema de salud, y reto para científicos, médicos e investigadores. En la actualidad son cientos de miles de personas que padecen de Lepra. El estigma y las discapacidades producidas los convierten en inhabilitados sociales. La aparición de la Bioética como nuevo paradigma del pensamiento médico, con sus principios de beneficencia, no maleficencia, autonomía y justicia, ha conmocionado al mundo de las ciencias médicas. Se realiza un análisis filosófico de un dilema bioético importante en nuestro medio: la ética médica y la Enfermedad de Hansen (Lepra), el humanismo como base de la relación médico paciente y la reflexión acerca del impacto psicosocial y económico de la Lepra. Se realizan algunas reflexiones que debe tener en cuenta el médico y enfermera de familia, así como el resto del Equipo Básico de Salud y los trabajadores de la Atención Primaria, con el paciente de Lepra. Se concluye que la relación médico-paciente en enfermos de Lepra requiere un humanismo vivo y desde el punto de vista psicosocial, hay que vencer los tabúes y la discriminación que desata el padecer de Lepra en la comunidad.
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    Tecnologías sanitarias educativas en el contexto de la lepra: Revisión de Alcance
    (Universidad de Murcia: servicio de publicaciones, 2025) Soares, Ana Beatriz da Silva; Barros, Mariah Kemily Silva; Vieira Silva, Cícera Renata Diniz; Sousa Fernandes, Petra Kelly Rabelo de; Nascimento, Maria Berenice Gomes; Fernandes, Marcelo Costa; Sin departamento asociado
    Introduction: The objective of this research was to map the production of educational health technologiesin the leprosy context at the global level.Material and methods: This is a scoping review conducted in accordance with the methodologicalstructures set forth by the Joanna Briggs Institute and the Preferred Reporting Items for Systematic reviews and Meta-Analyses checklist, extension for Scoping Reviews. Searches were carried out in the followingdatabases: Medline, Web of Science, Scopus, CINAHL, Embase, LILACS and BDENF, in addition to dissertation and these repositories, as well as in Google Scholar to support the review.Results: Twenty-five studies between 2008 and 2024 were included, where the country that produced themost educational technologies aimed at leprosy was Brazil and the main technologies demonstrated were apps.Conclusions: Educational technologies targeted at leprosy have developed significantly, benefiting bothhealth professionals and people affected by the disease. This progress not only improves the patients'quality of life but is also essential for prevention and awareness raising regarding leprosy