Browsing by Subject "Gene arrangement"

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    Ewing's sarcoma of the cervix: a case report and review of literature.
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2020) Zhang, Yangyang; Nong, Weixia; Ren, Yan; Jiang, Jinfang; Zhang, Haijun; Meng, Lian; Li, Qianru; Zhang, Qiaochu; Wang, Xiaomeng; Wang, Yang; Liu, Chunxia; Li, Feng
    Ewing’s sarcoma (ES) is a small cell malignant tumor that occurs in the bone of children or adolescents. ES can also occur in extraskeletal organs, such as the pancreas, thyroid, liver, proximal phalanx, and, rarely, cervix. Only 15 published case reports have discussed ES arising in the cervix. We report a 76-year- old woman who had groin mass. ES was diagnosed in accordance with morphological and immunohisto- chemical maps. Fluorescence in situ hybridization and RT-PCR (reverse transcription PCR) revealed ESWR1 gene rearrangement and fusion gene formation (EWS- FLI-1), both of which confirmed the diagnosis of ES. Although the patient underwent surgical resection, the patient died without chemotherapy and radiotherapy. This case is the first one to involve a patient aged over 70 years and the fifth one to show metastasis occurrence