Browsing by Subject "Fetal lung"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
- PublicationOpen AccessLight and electron microscopic study of fetal lung following maternal exposure to methylmercuric chloride(Murcia : F. Hernández, 1987) Curle, D.C.; Ray, M.; Persaud, T.V.N.Varying dose levels of methylmercuric chloride (MMC), 1000 ppm (5 mg through 15 mglkg of body weight), were administered via an intragastric tube to pregnant ICR SwissIWebster mice on day 9 of gestation. The animals were killed on gestational day 18 and the fetuses removed. Fetal lung sections were processed for light and electron microscopy. A group of animals treated with physiological saline in a similar mannner served as the controls. The fetal lungs from treated animals were hypoplastic and retarded in development. The severity of pulmonary changes increased with the dose-levels of MMC. Vacuolation and lysis of mitochondria were seen in fetal lungs. Mitochondrial damage increased in severity with doselevel of methylmercuric chloride.