Publication: Light and electron microscopic study of fetal lung following maternal exposure to methylmercuric chloride
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Date
1987
Authors
Curle, D.C. ; Ray, M. ; Persaud, T.V.N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Varying dose levels of methylmercuric
chloride (MMC), 1000 ppm (5 mg through 15 mglkg of
body weight), were administered via an intragastric tube
to pregnant ICR SwissIWebster mice on day 9 of
gestation. The animals were killed on gestational day 18
and the fetuses removed. Fetal lung sections were
processed for light and electron microscopy. A group of
animals treated with physiological saline in a similar
mannner served as the controls. The fetal lungs from
treated animals were hypoplastic and retarded in
development. The severity of pulmonary changes
increased with the dose-levels of MMC. Vacuolation and
lysis of mitochondria were seen in fetal lungs.
Mitochondrial damage increased in severity with doselevel
of methylmercuric chloride.
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