Browsing by Subject "DHA"

Now showing 1 - 4 of 4
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    Biocatalytic transesterification of salmon oil in ionic liquid media to obtain concentrates of omega-3 polyunsaturated fatty acids
    (Springer, 2024-06) Fuster, M.G.; Moulefera, I.; García Montalbán, Mercedes; Víllora Cano, Gloria; Ingeniería Química
    In this study, a biphasic system combining oil and ionic liquid was utilized for lipase-catalyzed transesterifcation of salmon oil and alcohol to concentrate n-3 PUFAs, notably EPA and DHA. Various process variables, such as enzyme type, quantity, alcohol chain length, temperature, reactant proportions, and ionic liquid selection, were systematically assessed to optimize the process and enhance the yield of these valuable fatty acids. It was found that the Novozym 435 and Lipolase 100L Type EX emerged as the most efective enzymes. The impact of varying alcohol chain lengths (C1–C8) was examined, revealing that the Novozym 435 enzyme displayed its peak synthetic activity with 2-propanol. The results revealed a substantial increase in the overall activity during the transesterifcation reaction when employing ILs featuring hydrophobic cations and anions with low nucleophilicity. Specifcally, the [omim+][NTf2 −] ionic liquid exhibited the highest level of activity. This research holds promise for more efciently and sustainably obtaining concentrated n-3 PUFAs from fsh oil while reducing environmental impact relative to other existing concentration processes.
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    Child Head Circumference and Placental MFSD2a Expression Are Associated to the Level of MFSD2a in Maternal Blood During Pregnancy
    Sanchez-campillo Muñoz, M.; Ruiz Palacios, M.; Prieto Sánchez, María Teresa; Blanco Carnero, José Eliseo; Zornoza Moreno, M.; Ruiz Pastor, M. J.; Demmelmair, H.; Sánchez-Solís de Querol, Manuel; Koletzko, B.; Larqué Daza, Elvira; Ruiz Alcaraz, Antonio José; Cirugía, Pediatría y Obstetricia y Ginecología
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    Milk fat globule membrane plus milk fat increase docosahexaenoicacid availability in infant formulas
    (2022-10-25) Gazquez Garcia, A.; Sabater Molina, María; Domínguez-lópez, I.; Sanchez-campillo Muñoz, M.; Torrento, N.; Tibau, J.; Moreno-muñoz, J. A.; Rodríguez-palmero, M.; López-sabater, M. C.; Larque Daza, E.; Fisiología
    Purpose Milk fat globule membrane (MFGM) has components with emulsifer properties that could afect the provision of substrates to the brain. We evaluated the efects of MFGM plus milk fat addition to infant formulas on docosahexaenoic acid (DHA) availability and gut development. Methods In Experiment 1, suckling piglets were divided into 3 groups: Group L1 (n=8): fed with a vegetal fat formula with palm oil; L2 (n=8): canola oil formula and L3 (n=8): milk fat+canola oil+1% Lacprodan (3% MFGM of total protein content). In Experiment 2, Group L4 (n=7): fed with canola oil+1% Lacprodan (3% MFGM) and Group L5 (n=5): milk fat+canola oil+2% Lacprodan (6% MFGM). All formulas contained 0.2% DHA and 0.2% arachidonic acid. Results In Experiment 1, DHA was similar among the groups in both total fatty acids and plasma phospholipids (PL). However, 3% MFGM (L3) increased signifcantly the proportion of DHA and LC-PUFA n-3 in liver total fatty acids, jejunum, and also in jejunum PL respect to the other formulas. There were no changes in gut histology, cell proliferation, apoptosis, or brain DHA content. In Experiment 2, higher MFGM dose was used. Then, higher DHA was not only found in peripheral tissues of 6% MFGM (L5) piglets but also in plasma PL, while a similar trend was observed in cortex PL (p=0.123). Conclusion In conclusion, MFGM plus milk fat may increase DHA availability of infant formulas which could contribute to their benefcial health efects.
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    Omega-3 y fisiología: funciones celulares, inflamatorias y metabólicas en el organismo
    (0008-05-26) Victoria Montesinos, Desirée ; Mateo Orcajada, Adrián; Fisiología
    Los ácidos grasos omega-3 son lípidos esenciales que participan en funciones fisiológicas importantes. Forman parte de las membranas celulares, contribuyen a su fluidez y favorecen una correcta comunicación entre células. Además, intervienen en la regulación de la respuesta inflamatoria, la función cardiovascular, el metabolismo lipídico y el desarrollo y funcionamiento del sistema nervioso. Entre los principales omega-3 destacan el ácido alfa-linolénico (ALA), el ácido eicosapentaenoico (EPA) y el ácido docosahexaenoico (DHA).