Browsing by Subject "Correlations"

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    ¿Las correlaciones altmétricas/métricas tradicionales se ven afectadas por los planes de marketing en medios sociales de las revistas? El caso de la revista Comunicar
    (Universidad de Murcia, 2018) González-Fernández-Villavicencio, Nieves; Moya-Orozco, Víctor Manuel
    En este estudio se analizan las correlaciones entre los datos aportados por los sistemas de citas tradicionales y las altmétricas de los artículos publicados durante cinco años en la revista Comunicar, que destaca sobre las demás de su área por su avanzado plan de marketing en medios sociales. Además, se presentan los indicadores que ofrecen datos altmétricos y se lleva a cabo una revisión bibliográfica sobre las publicaciones que han tratado el tema de las correlaciones, destacando relaciones débiles entre métricas tradicionales y altmétricas. Del estudio de correlaciones sobre los datos de la revista, se confirman las débiles relaciones entre los tipos de métricas y se concluye que son significativas para evaluar el nivel de atención que reciben las publicaciones en distintos ámbitos. Como recomendación a los investigadores y editores se destaca la importancia de utilizar los medios sociales, en especial Mendeley y Twitter, para dar visibilidad y difundir la producción científica.
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    The expression of death receptor systems TRAIL-R1/-R2/-R4, CD95 and TNF-R1 and their cognate ligands in pancreatic ductal adenocarcinoma
    (2019) Gärtner, Friederike; Krüger, Sandra; Röder, Christian; Trauzold, Anna; Röcken, Christoph; Kalthoff, Holger
    The expression of five members of the TNF receptor superfamily and two of their ligands in human pancreatic ductal adenocarcinoma were investigated by immunohistochemistry. 41 patients with histologically confirmed ductal carcinoma of the pancreas were enrolled in this study in order (i) to compare the individual TNFR-SF expression and their ligands in PDAC-cells and (ii) to investigate their correlation with survival data. All patients had undergone pancreaticoduodenectomy and were staged as pT3N1M0. Immunostaining was done on FFPE tissue sections of the tumor tissue, using antibodies directed against TRAIL-Receptor-1, -2 and -4, TRAIL, CD95, TNF-Receptor-1 and TNF-α. The intensity and quantity of immunostaining were evaluated separately for tumor cell cytoplasm and tumor cell nucleus. Immunostaining results were correlated with each other and with patient survival. All proteins were found to be expressed in the majority of the tumor cells. The expression (i) of the following members of TNFR-SF and their ligands correlated with each other: TNF-Receptor-1 and TNFα (cytoplasmatic scores, p=0.001), TNF-Receptor 1 and TRAIL (nuclear antigen expression p=0.005 and the main score p=0.001, which contains the overall intracellular antigen expression), TNF-Receptor 1 and CD95 (main score, p=0.001), TRAIL-Receptor-1 and TRAIL-Receptor-2 (nuclear parameters, p=0.023), TRAIL-Receptor-4 and TRAIL (main score p=0.041). In addition (ii), high cytoplasmatic expression of TNFReceptor-1 and a strong cytoplasmatic and nuclear expression of CD95 correlated significantly with a better prognosis of the PDAC patients