Browsing by Subject "Cancer patients"

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    Chronodisruption and ambulatory circadian monitoring in cancer patients: beyond the body clock
    (Springer, 2022-01-21) Almaida Pagán, Pedro Francisco; Torrente, Maria; Campos Martínez, Manuel; Provencio, Mariano; Madrid, Juan A; Franco, Fabio; Rodriguez Morilla, Beatriz; Cantos, Blanca; Sousa, Pedro A; Martinez Madrid, Maria J; Pimentao, Joao; Rol, Maria A; Fisiología
    Purpose of Review Circadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease. Recent Findings In recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications. Summary This review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the stateof-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.
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    Chronodisruption and ambulatory circadian monitoring in cancer patients: beyond the body clock
    (Springer, 2022-01-21) Almaida Pagan, Pedro F.; Torrente, María; Campos Martínez, Manuel; Provencio, Mariano; Madrid, Juan Antonio; Franco, Fabio; Rodríguez Morilla, Beatriz; Cantos, Blanca; Sousa, Pedro A.; Martínez Madrid, María José; Pimentao, Joao; Rol de Lama, María de los Ángeles; Fisiología
    Purpose of ReviewCircadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions, such as cell proliferation, inflammation, and DNA damage response. Accumulating epidemiological and genetic evidence indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research may offer new options for increasing cancer treatment effectiveness and would encompass the prevention, diagnosis, and treatment of this disease.Recent FindingsIn recent years, there has been a significant development and use of multi-modal sensors to monitor physical activity, sleep, and circadian rhythms, allowing, for the very first time, scaling accurate sleep monitoring to epidemiological research linking sleep patterns to disease, and wellness applications providing new potential applications.SummaryThis review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the state-of-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer research.