(Murcia : F. Hernández, 1988) Bianciardi, G.; Battistelli, S.; Toti, P.; Vallesi, G.; Weber, G.
Biochemical and morphological data have
shown that the circulating platelets are deeply altered in
patients with chronic mielogenous leukemia. In this
report we describe the results of ultrastructural
morphometry performed by means of a computerized
device of the platelet shape (ultra-thin sectioned
platelets) and of the platelet plasma-membrane (freezefractured
platelets). Platelets appeared deeply modified:
reduced mean platelet area and perimeter, increased
surface density of the openings of the surface connected
canalicular system, abnormal features of the platelet
cytoplasm and some aspects of platelets joined together
even if with heterogeneity in these findings did appear
from patient to patient.