Histology and histopathology Vol.39, nº8 (2024)

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The multiple facets of the club cell in the pulmonary epithelium
(Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2024) López Valdez, Nelly; Rojas Lemus, Marcela; Bizarro-Nevares, Patricia; González Villalva, Adriana Elizabeth; Casarrubias Tabarez, Brenda; Cervantes Valencia, María Eugenia; Ustarroz-Cano, Martha; Morales Ricardes, Guadalupe; Mendoza Martínez, Shamir; Guerrero Palomo, Gabriela; Fortoul, Teresa I.
The non-ciliated bronchiolar cell, also referred to as “club cell”, serves as a significant multifunctional component of the airway epithelium. While the club cell is a prominent epithelial type found in rodents, it is restricted to the bronchioles in humans. Despite these differences, the club cell's importance remains undisputed in both species due to its multifunctionality as a regulatory cell in lung inflammation and a stem cell in lung epithelial regeneration. The objective of this review is to examine different aspects of club cell morphology and physiology in the lung epithelium, under both normal and pathological conditions, to provide a comprehensive understanding of its importance in the respiratory system.