Datos de Investigación

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Open Access
Data research: Validation of quality, perceived value, future practice intention and satisfaction scale of activity charter focused on nautic business development.
(0001-01-23) Borrego Balsalobre, Francisco José; Actividad Física y Deporte
Open Access
Dataset used for the study entitled: Sex Differences in Match Demands: Equivalent Open-Play Intensity but Distinct Static Loading and Discipline Profiles in Elite Rugby Union
(0004-12-04) Villarejo García, Diego; Actividad Física y Deporte; Facultades de la UMU::Facultad de Ciencias del Deporte
Embargo
Sexual function and intimate partner violence in middle- aged women: a community-based, dual-focus study in Spain
(The Menopause Society, 0016-10-16) María M. Martínez- Madrid; González Cuello, Ana María; Arnau Sánchez, José; María M. Martínez Madrid; Enfermería; Ana González - Cuello; José Arnau-Sánchez; Facultades de la UMU::Facultad de Enfermería
Objective: To evaluate the association between sexual function and intimate partner violence (IPV) among sexually active, middle-aged women in Spain, examining each outcome in separate cross-sectional models. Methods: This cross-sectional study included 451 women (40- 64 y) randomly recruited from primary care settings in southeastern Spain. Participants completed the 6-item Female Sexual Function Index (FSFI-6), the Woman Abuse Screening Tool (WAST), and a general sociodemographic and clinical questionnaire. Factors associated with low sexual function and a positive IPV screen were analyzed using generalized linear models of the Poisson family to estimate adjusted prevalence ratios (aPR). Results: The mean age of participants was 50.09 ± 7.05 years. The prevalence of low sexual function (FSFI-6 score ≤ 19) was 33.7%, and the prevalence of a positive IPV screen (WAST score ≥ 14) was 16.6%. Low sexual function was higher among women with a positive IPV screen compared with those without (77.3% vs. 25.0%, P < 0.001). In the multivariate model, a positive IPV screen was related to a higher prevalence of low sexual function (aPR: 2.57; 95% CI: 2.04-3.25). Conversely, low sexual function was linked to a positive IPV screen (aPR: 4.67; 95% CI: 2.78-7.85). Spanish Roma ethnicity was also associated with IPV (aPR: 3.51; 95% CI: 2.14-5.74). Conclusions: Low sexual function and a positive IPV screen were statistically associated in this community-based sample of middle-aged women. A higher prevalence of IPV was observed among certain ethnic minorities. These associations persisted after adjustment for sociodemographic and clinical factors.
Open Access
Biomarker-based assessment of somatostatin-6 immunomodulation in gilthead Seabream: From serum proteins to skin mucus enzymes
(0022-10-20) Jose Carlos Campos Sánchez; Cristóbal Espinosa-Ruiz; Francisco A. Guardiola; Esteban Abad, María de los Ángeles; Guardiola Abellán, Francisco Antonio; Marín Parra, Claudia; Biología Celular e Histología
This study evaluated the immunomodulatory role of somatostatin-6 (SST6) in gilthead seabream (Sparus aurata) using a validated inflammation model induced by λ-carrageenan and a comprehensive panel of serum and skin mucus biomarkers. SST6 was administered at 1 nM and 2 nM, and its effects were assessed in these matrices. The λ-carrageenan model triggered a local inflammatory response with reduced peroxidase, esterase, and protease activities in skin mucus, consistent with the resolution phase of innate immunity. SST6 at 1 nM enhanced serum complement activity without affecting acute-phase proteins, suggesting reinforcement of basal immune surveillance in the host. When combined with λ-carrageenan, SST6 promoted an increase in serum immunoglobulin levels and a selective shift in proteinogram fractions (α2-globulin), while further decreasing the oxidative and proteolytic activities in skin mucus. Correlation analysis revealed the coordinated regulation of key mucosal enzymes, reinforcing the functional integration of local immune responses. These results indicate that SST6 facilitates an early transition from innate to adaptive immunity while preserving the integrity of the mucosal barrier. Furthermore, this study provides the first evidence of complement activation by SST6 in fish and highlights the value of integrating biomarker-based tools to monitor immunophysiological responses and test bioactive compounds in aquaculture research.
Restricted
Role of the C-sheet in the maturation of N-glycans on antithrombin: functional relevance of pleiotropic mutations
(2014-04-15) Águila Martínez, Sonia; Navarro Fernández, José Luis; Bohdan, N.; Gutiérrez Gallego, R.; Morena Barrio, María Eugenia de la; Vicente García, Vicente; Corral de la Calle, Javier; Martínez-Martínez, I.; Medicina Interna; Facultad de Medicina
Open Access
Heritability of sleep quality in a middle-aged twin sample from Spain
(2018) Gregory, Alice M.; Madrid Valero, Juan José; Martínez Selva, José María; Ordoñana Martín, Juan Ramón; Sánchez Romera, Juan Francisco; Anatomía Humana y Psicobiología
Study objectives: Sleep quality is associated with health throughout the life span, which is particularly salient in middle-age and older adulthood. Sleep quality appears to be influenced by both genetic and environmental factors. However, there is still limited information about genetic influences on sleep quality in middle-aged adults, and particularly in those from certain geographical locations. We estimated the magnitude of genetic and environmental influences on sleep quality in a representative sample of middle-aged Spanish twins. Methods: The sample comprised 2150 individuals born between 1939 and 1966, who participate in the Murcia Twin Registry. In order to estimate the heritability of sleep quality variables we performed univariate analyses for the global score on the Pittsburgh sleep quality index and for each of its components. Results: We found moderate but significant heritability (34%) for sleep quality. The genetic variance of the components of the Pittsburgh index ranged from 30% to 45%, except for sleep efficiency for which no genetic influence could be detected. In summary, there was a moderate genetic influence on most dimensions of sleep quality in a sample of adult male and female twins. Shared environment influences were not found. Conclusions: This study adds new information regarding the underlying determinants of sleep quality by providing heritability estimates in a middle-aged population-based representative sample from a geographical location that has not been included in studies of this type previously. This could provide a reference point for future research regarding sleep research in middle-age.
Open Access
Dataset title: Industrial Control System (ICS) Network Traffic Dataset for Anomaly Detection
(2019) Fernández Maimó, Lorenzo; Peráles Gómez, Ángel Luis; Huertas Celdrán, Alberto; García Clemente, Félix Jesús; Cadenas Sarmiento, Cristina; Canto Masa, Carlos Javier del; Méndez Nistal, Rubén; Ingeniería y Tecnología de Computadores
Open Access
Datos del manuscrito "Detection of protection benefits on predatory fishes depends on the census methodology adopted", por Rojo I, Irigoyen AJ, Cuadros A, Calò A, Pereñíguez JM, Hernández-Andreu R, Félix-Hackradt F, Carreño F, Hackradt CW & García-Charton JA
(2020-03-30) Rojo Moreno, Irene; García Charton, José Antonio; García Charton, José Antonio; Ecología e Hidrología
Base de datos de peces de fondos rocosos utilizando diferentes métodos de censo visual en 5 reservas marinas del Mediterráneo occidental, que forman parte del trabajo de tesis doctoral de la primera autora, y utilizados en el artículo "Detection of protection benefits on predatory fishes depends on the census methodology adopted"
Open Access
Dataset for: Experimental validation of SIRT1 as a direct target of miR-199a-5p and its restoration via antimiR-199a therapy in post-MI remodeling
(2020-04-24) Lax Pérez, Antonio Manuel; Medicina Interna; Facultades de la UMU::Facultad de Medicina
Open Access
Datos del manuscrito "exceptionally high but still growing predatory reef biomass after 23 years of protection in a Mediterranean Marine Protected Area"
(2020-05-25) Rojo Moreno, Irene; Anadón, José Daniel; García Charton, José Antonio; García Charton, José Antonio; Ecología e Hidrología
Datos de abundancia y biomasa de peces en arrecifes rocosos de la reserva marina de Cabo de Palos - Islas Hormigas, obtenidos mediante. censos de peces en inmersión con escafandra autónoma, durante el periodo 1996-2018
Open Access
TCF7L2 regulates postmitotic differentiation programmes and excitability patterns in the thalamus
(The company of Biologists Ltd., 2020-08-25) Andrzej Lipiec, Marcin; Bem, Joanna; Koziński, Kamil; Chakraborty, Chaitali; Urban-Ciećko, Joanna; Zajkowski, Tomasz; Dabrowski, Michał; Mateusz Szewczyk, Łukasz; Toval, Ángel; Ferrán Bertone, José Luis; Nagalsk, Andrzej; Wiśniewska, Marta Barbara; Anatomía Humana y Psicobiología; Facultad de Medicina
Neuronal phenotypes are controlled by terminal selector transcription factors in invertebrates, but only a few examples of such regulators have been provided in vertebrates. We hypothesised that TCF7L2 regulates different stages of postmitotic differentiation in the thalamus, and functions as a thalamic terminal selector. To investigate this hypothesis, we used complete and conditional knockouts of Tcf7l2 inmice. The connectivity and clustering of neurons were disrupted in the thalamo-habenular region in Tcf7l2−/− embryos. The expression of subregional thalamic and habenular transcription factors was lost and region-specific cell migration and axon guidance genes were downregulated. In mice with a postnatal Tcf7l2 knockout, the induction of genes that confer thalamic terminal electrophysiological features was impaired. Many of these genes proved to be direct targets of TCF7L2. The role of TCF7L2 in terminal selection was functionally confirmed by impaired firing modes in thalamic neurons in the mutantmice. These data corroborate the existence of master regulators in the vertebrate brain that control stage-specific genetic programmes and regional subroutines, maintain regional transcriptional network during embryonic development, and induce terminal selection postnatally.
Open Access
Using high-power ultrasounds in red winemaking: effect of operating conditions on wine physico-chemical and chromatic characteristics
(Elsevier, 2020-11-27) Pérez Porras, Paula; Bautista Ortín, Ana Belén; Jurado, Ricardo; Gómez Plaza, Encarna; Tecnología de Alimentos, Nutrición y Bromatología; Facultad de Veterinaria
This study presents the application of high-power ultrasounds (US) to crushed grapes using winery-scale equipment and studies, for the first time at this scale, how the frequency of the ultrasounds affects the extraction of phenolic compounds from grapes and the chromatic and physico-chemical characteristics of the finished wines, in an attempt to optimize the maceration process. The results showed how US modified the physical characteristics of the grape skin, facilitating phenolic extraction and improving the wine chromatic characteristics but only produced slight differences in the physico-chemical characteristics of the finished wines. The two different frequencies applied led to some differences in the wine phenolic composition, especially higher tannin extraction at 20 kHz whereas anthocyanin extraction was favoured at 28 kHz. Wines made with sonicated grapes and 72 h of skin maceration time were chromatically very similar to control wines with four more days of skin contact, indicating that this technological process may increase the working capacity of the winery by allowing a reduction of more than 50% in the maceration time.
Open Access
Data set for: Quantitative profiling of cardiac remodeling and antimiR-199a therapeutic efficacy in a murine MI model
(2020-12-09) Antonio Lax; Medicina Interna; Facultades de la UMU::Facultad de Medicina
Open Access
Plan de gestión del proyecto Conceptos metodológicos y métodos activos de aprendizaje para la mejora de las competencias docentes del profesorado (PGC2018-094491-B-C33)
(2020-12-31) Sánchez Ibáñez, Raquel; Miralles Martínez, Pedro; Gómez Carrasco, Cosme Jesús; Didáctica de las Ciencias Matemáticas y Sociales; Facultades de la UMU::Facultad de Educación
El objetivo de este proyecto es evaluar las competencias docentes del profesorado en formación de Educación Primaria y Secundaria en torno a un programa de intervención que detecte las necesidades previas de los futuros docentes, pero que además permita analizar su capacidad de diseñar e implementar actividades y/o secuencias formativas en las que incorporen conceptos de segundo orden sobre historia a través de métodos activos de aprendizaje. La finalidad última es mejorar el proceso de interrelación entre los planteamientos teóricos y metodológicos en las aulas de formación del profesorado, con la reflexión y el análisis crítico de la praxis docente en su fase de prácticas curriculares. Si bien es cierto que en este proyecto pretendemos evaluar la eficacia de un programa de intervención en la mejora de las competencias profesionales, además intentaremos incidir en la transferencia de esas competencias a la práctica docente. A través de ese doble objetivo, y de un análisis multivariable (combinando una gran diversidad de instrumentos de recogida y análisis de la información, así como diferentes técnicas cuantitativas y cualitativas) queremos validar pautas y estrategias de actuación que permitan formar un profesorado competente, crítico y reflexivo sobre su praxis profesional.
Open Access
Conjunto de Datos del artículo Análisis documental sobre los riesgos y las posibilidades de internet para los menores. Pautas educativas dirigidas a familias.
(2021) López Vicent, Patricia; Hernández Prados, María de los Ángeles; Gamboa Gil de Sola, Gonzalo; Teoría e Historia de la Educación
Open Access
Data set for: Cardiac remodeling data associated with antimiR-199a treatment in a mouse model of myocardial infarction
(2021-02-16) Lax Pérez, Antonio Manuel; Medicina Interna; Facultades de la UMU::Facultad de Medicina
This repository contains data associated with Figure 2 from the article “The miRNA199a/SIRT1/P300/Yy1/sST2 signaling axis regulates adverse cardiac remodeling following MI” (DOI: 10.1038/s41598-021-82745-9), including the complete figure, supporting quantification data, and the original unprocessed images underlying panel h (WGA staining).
Open Access
Dataset used for: AntimiR-199a treatment protects against cardiac hypertrophy and fibrosis following myocardial infarction
(2021-02-16) Lax Pérez, Antonio Manuel; Medicina Interna
Open Access
Data Set: review implementation of digital tools and processes in higher education institutions 2021
(2021-04) Castañeda Quintero, Linda Johanna; Esteve Mon, Francesc; Postigo Fuentes, Ana Yara; Didáctica y Organización Escolar
Restricted
S3 Dataset
(2021-04-13) Espín López, Juan Manuel; Marín-Blázquez, Javier G.; Esquembre, Francisco; Martínez Pérez, Gregorio; Huertas Celdrán, Alberto; Matemáticas
The S3 dataset contains the behavior (sensors, statistics of applications, and voice) of 21 volunteers interacting with their smartphones for more than 60 days. The type of users is diverse, males and females in the age range from 18 until 70 have been considered in the dataset generation. The wide range of age is a key aspect, due to the impact of age in terms of smartphone usage. To generate the dataset the volunteers installed a prototype of the smartphone application in on their Android mobile phones. All attributes of the different kinds of data are writed in a vector. The dataset contains the fellow vectors: Sensors: This type of vector contains data belonging to smartphone sensors (accelerometer and gyroscope) that has been acquired in a given windows of time. Each vector is obtained every 20 seconds, and the monitored features are: - Average of accelerometer and gyroscope values. - Maximum and minimum of accelerometer and gyroscope values. - Variance of accelerometer and gyroscope values. - Peak-to-peak (max-min) of X, Y, Z coordinates. - Magnitude for gyroscope and accelerometer. Statistics: These vectors contain data about the different applications used by the user recently. Each vector of statistics is calculated every 60 seconds and contains : - Foreground application counters (number of different and total apps) for the last minute and the last day. - Most common app ID and the number of usages in the last minute and the last day. - ID of the currently active app. - ID of the last active app prior to the current one. - ID of the application most frequently utilized prior to the current application. - Bytes transmitted and received through the network interfaces. Voice: This kind of vector is generated when the microphone is active in a call o voice note. The speaker vector is an embedding, extracted from the audio, and it contains information about the user's identity. This vector, is usually named "x-vector" in the Speaker Recognition field, and it is calculated following the steps detailed in "egs/sitw/v2" for the Kaldi library, with the models available for the extraction of the embedding. A summary of the details of the collected database. - Users: 21 - Sensors vectors: 417.128 - Statistics app's usage vectors: 151.034 - Speaker vectors: 2.720 - Call recordings: 629 - Voice messages: 2.091
Open Access
Sex‑dependent effects of forced exercise in the body composition of adolescent rats
(Nature Research, 2021-05-12) Kutsenko Shchegolska, Yevheniy; Barreda, A.; Toval Sánchez, José Ángel; Garrigos, D.; Martínez Morga, Marta; Ribeiro do Couto, Bruno; Ferrán Bertone, José Luis; Anatomía Humana y Psicobiología; Facultad de Medicina
Determining the body composition during adolescence can predict diseases such as obesity, diabetes, and metabolic syndromes later in life; and physical activity became an effective way to restore changes in body composition. However, current available literature assessing the body composition before, during and after adolescence in female and male rodents by in vivo techniques is scarce. Thus, by using computerized tomography, we aimed to define the baseline of the weight and body composition during the adolescence and young adulthood of female and male Sprague–Dawley rats (on P30, P60 and P90) under standard diet. Then, we determined the effect of 18 days of forced exercise on the body weight and composition during the early adolescence (P27-45). The highest percentual increments in weight, body volume and relative adipose contents occurred during the female and male adolescence. Forced running during the early adolescence decreased weight, body volume and relative adipose delta and increment values in males only. The adolescence of rats is a period of drastic body composition changes, where exercise interventions have sex-dependent effects. These results support a model that could open new research windows in the field of adolescent obesity.

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