Trophoblast-derived proteins and their effects on the pathogenesis of preeclampsia

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dc.contributor.authorYanan Wang
dc.contributor.authorXueling Chen
dc.contributor.authorHaifeng Zhang
dc.contributor.authorYunshan Xue
dc.contributor.authorHaibin Chen
dc.contributor.authorJu Yang
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-12-17T09:34:46Z
dc.date.available2025-12-17T09:34:46Z
dc.date.issued2026
dc.description.abstractTrophoblast cells are crucial structural units of the placenta, responsible for maintaining its integrity and function. These cells synthesize and secrete specific proteins that play essential roles in placental vascularization, maternal and fetal immune tolerance, and other critical processes. An abnormal level of trophoblast-derived secreted proteins has been closely linked to pregnancy-related diseases. Preeclampsia, a severe complication of pregnancy characterized by de-novo development of hypertension and proteinuria after 20 weeks of gestation, poses significant health risks to both the mother and fetus. This article reviews several key trophoblast-derived proteins that are widely recognized for their roles in preeclampsia. The specific mechanisms of action and interconnections among these proteins in preeclampsia are discussed, along with novel insights into the underlying pathological mechanisms of this disease.
dc.formatapplication/pdf
dc.format.extent14
dc.identifier.doihttps://doi.org/10.14670/HH-18-930
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/180869
dc.languageeng
dc.publisherEditum
dc.relationSin financiacion externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectTrophoblast cells
dc.subjectPlacenta development
dc.subjectPathogenesis
dc.subjectPreeclampsia
dc.subjectCell-specific secreted proteins
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleTrophoblast-derived proteins and their effects on the pathogenesis of preeclampsia
dc.typeinfo:eu-repo/semantics/article
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Histology and histopathology, Vol.41, Nº1, (2026)