Therapeutic potential of porphyran in mitigating ischemia-reperfusion injury in gerbil hippocampus

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dc.contributor.authorTae-Kyeong Lee
dc.contributor.authorJoon Ha Park
dc.contributor.authorDae Won Kim
dc.contributor.authorChoong-Hyun Lee
dc.contributor.authorMoo-Ho Won
dc.contributor.authorIl Jun Kang
dc.contributor.authorJi Hyeon Ahn
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-12-19T08:54:07Z
dc.date.available2025-12-19T08:54:07Z
dc.date.issued2026
dc.description.abstractCerebral ischemia-reperfusion (IR) injury is a critical pathological event that leads to extensive neuronal loss, neuroinflammation, and blood-brain barrier (BBB) dysfunction. Porphyran, a sulfated polysaccharide derived from Porphyra spp., has demonstrated anti-inflammatory and neuroprotective effects in various neurological conditions. This study aimed to evaluate the post-ischemic therapeutic potential of porphyran in a gerbil model of transient forebrain ischemia. Our findings reveal that porphyran administration (50 mg/kg orally once daily for five days) following IR significantly mitigated IR-induced cognitive decline, as evidenced by the Y-maze test, but porphyran treatment did not significantly prevent neuronal death in the CA1 subregion of the hippocampus, as revealed by Cresyl Violet (CV) and Fluoro-Jade B (FJB) staining. However, porphyran treatment after IR injury effectively attenuated the IR-induced decrease in acetylcholine (ACh) levels, suggesting potential preservation of cognitive function in surviving neurons. Furthermore, porphyran significantly mitigated microglial activation and reduced the levels of proinflammatory cytokines (IL-1β, IL-6, and TNF-α), indicating its anti-inflammatory properties. Additionally, porphyran administration reduced BBB disruption, as evidenced by decreased extravasation of immuno-globulin G (IgG), suggesting a role in maintaining vascular integrity. In summary, although porphyrin administration after IR does not protect pyramidal neurons directly, it may improve cognitive function by mitigating ACh depletion, suppressing microglial activation, and reducing inflammatory cytokine levels
dc.formatapplication/pdf
dc.format.extent10
dc.identifier.doihttps://doi.org/10.14670/HH-18-947
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/181589
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.relationSin financiacion externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAcetylcholine
dc.subjectPyramidal neurons
dc.subjectMicroglia
dc.subjectProinflammatory cytokines
dc.subjectBlood-brain barrier
dc.subjectCognition
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleTherapeutic potential of porphyran in mitigating ischemia-reperfusion injury in gerbil hippocampus
dc.typeinfo:eu-repo/semantics/article
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Histology and histopathology, Vol.41, Nº1, (2026)