The evolution of mast cells across all vertebrate classes: The mystery continues

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dc.contributor.authorStefano Bacci
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-12-17T08:55:15Z
dc.date.available2025-12-17T08:55:15Z
dc.date.issued2026
dc.description.abstractThe paper examines what the mast cell, a cell that arose in urochordates and reached humans with the same morphological profile, is used for. Activated mast cells contribute to the regulation of the local immune response and major inflammation and healing processes with the help of a broad range of mediators. Located primarily at the interface between the host and the external environment, mast cells are widely distributed. The local microenvironment directly affects mast cell development, phenotype, and function, which in turn affects the cells' capacity to identify and react to different stimuli by releasing a variety of physiologically active mediators. By interacting with a range of other cells involved in physiological and immunological responses, mast cells can react to changes in their surroundings and serve as first responders in dangerous situations. Consequently, the mast cell’s crucial function in innate and adaptive immunity, including immuno-logical tolerance, has come to light more frequently. On the other hand, mast cell malfunction has identified these cells as the primary culprits in a number of autoimmune illnesses, cancer, and chronic allergic/inflammatory conditions.
dc.formatapplication/pdf
dc.format.extent9
dc.identifier.doihttps://doi.org/10.14670/HH-18-926
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/180810
dc.languageeng
dc.publisherEditum
dc.relationSin financiacion externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectImmune System
dc.subjectMast Cells
dc.subjectVertebrates
dc.subjectEvolution
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleThe evolution of mast cells across all vertebrate classes: The mystery continues
dc.typeinfo:eu-repo/semantics/article
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Histology and histopathology, Vol.41, Nº1, (2026)