Loss of PDE10A is associated with metastasis of colon adenocarcinoma

Simple item page
dc.contributor.authorNicholas Nuechterlein
dc.contributor.authorVinny Ha
dc.contributor.authorAllison Shelbourn
dc.contributor.authorAshis Chowdhury
dc.contributor.authorYeshavanth K Banasavadi-Siddegowda
dc.contributor.authorJerzy Lasota
dc.contributor.authorMarkku Miettinen
dc.contributor.authorPatrick J. Cimino
dc.contributor.authorSumaita Arowa
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2026-01-07T15:59:33Z
dc.date.available2026-01-07T15:59:33Z
dc.date.issued2026
dc.description.abstractPhosphodiesterase 10A (PDE10A), located on cytoband 6q27, acts as a haploinsufficient tumor suppressor in glioblastoma, where its loss drives aggressive tumor behavior and is associated with a proneural-to-mesenchymal (PN-MES) shift. Lever-aging bioinformatic analyses of The Cancer Genome Atlas (TCGA) pan-cancer dataset, we identified gastrointestinal carcinomas, specifically stomach adenocarcinoma and colon adenocarcinoma, as cancers where 6q27/PDE10A loss is prognostic. In both stomach adenocarcinoma and colon adenocarcinoma, PDE10A loss was associated with reduced overall survival (OS) and progression-free survival (PFS). Additionally, PDE10A loss correlated with increased lymphatic invasion and higher AJCC pathologic nodal stage in colon adenocarcinoma. In an independent institutional cohort, immunohistochemical analysis showed lower PDE10A expression in metastatic colon adenocarcinomas compared to primary tumors. Furthermore, PDE10A loss and decreased protein expression corresponded with an epithelial-to-mesenchymal transition (EMT) phenotype in both cohorts, consistent with the known PN-MES shift observed in glioblastoma. In summary, PDE10A loss in colon adenocarcinoma is associated with decreased OS and PFS, more frequent lymphatic invasion, higher pathologic nodal stage, metastatic disease, and an EMT phenotype.
dc.formatapplication/pdf
dc.format.extent9
dc.identifier.doihttps://doi.org/10.14670/HH-18-951
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/184209
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.relationSin financiacion externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPhosphodiesterase
dc.subjectBiomarker
dc.subjectColon Carcinoma
dc.subjectColon Cancer
dc.subjectPDE10A
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleLoss of PDE10A is associated with metastasis of colon adenocarcinoma
dc.typeinfo:eu-repo/semantics/article
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Arowa-41-235-243-2026.pdf
Size:
5.11 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Histology and histopathology, Vol.41, Nº2, (2026)