Expression of mucins MUC1 and MUC4 in curative resected gallbladder adenocarcinoma

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dc.contributor.authorMichiyo Higashi
dc.contributor.authorIkumi Kitazono
dc.contributor.authorSeiya Yokoyama
dc.contributor.authorTakashi Tasaki
dc.contributor.authorHirotsugu Noguchi
dc.contributor.authorMari Kirishima
dc.contributor.authorMiki Murakami
dc.contributor.authorAkihide Tanimoto
dc.contributor.authorMasako Noumi
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-12-17T09:56:00Z
dc.date.available2025-12-17T09:56:00Z
dc.date.issued2026
dc.description.abstractBackground and Aims. Gallbladder adenocarcinoma (GBAC) is associated with high mortality because of the difficulty in its early detection and treatment. Therefore, identifying prognostic factors is crucial for managing patients with GBAC. We aimed to elucidate the relationship between immunohisto-chemical profiles of mucin expression, clinico-pathological behavior, and prognosis for curatively resected gallbladder adenocarcinoma (GBAC) and to prove that mucin expression is a prognostic factor for GBAC. Methods. We examined the expression of mucins (MUC1, MUC2, and MUC4) using immunohisto-chemical analyses and compared the prevalence of each mucin with clinicopathological features in patients with early-stage (stage 0 to IIB) GBAC. Results. MUC1 expression was significantly expressed in patients with GBAC with lymphatic invasion, vascular invasion, perineural invasion, and recurrence. MUC2 was significantly expressed in patients with GBAC with perineural invasion and recurrence but not with prognosis. Patients with MUC1-high expression exhibited worse prognoses than those with MUC1-low expression. In contrast, patients with positive MUC4 expression had significantly better prognoses than those without MUC4 expression. Conclusion. The expression of MUC1 and MUC4 in GBAC is an independent prognostic factor for survival and a useful marker for predicting the outcomes of patients with GBAC.
dc.formatapplication/pdf
dc.format.extent8
dc.identifier.doihttps://doi.org/10.14670/HH-18-928
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/180690
dc.languageeng
dc.publisherEditum
dc.relationSin financiacion externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMUC1
dc.subjectMUC4
dc.subjectGallbladder adenocarcinoma (GBAC)
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleExpression of mucins MUC1 and MUC4 in curative resected gallbladder adenocarcinoma
dc.typeinfo:eu-repo/semantics/article
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Histology and histopathology, Vol.41, Nº1, (2026)