Publication: Regulation of spermatogonial stem cell self-renewal and proliferation in mammals
Authors
Wei, Bang Hong ; Hao, Shuang Li ; Yang, Wan Xi
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-461
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info:eu-repo/semantics/article
Description
Abstract
The generation of functional sperm relies on
spermatogonial stem cells (SSCs) as they can maintain a
stem cell pool for continuous generation of functional
spermatozoa. The maintenance of SSCs is regulated by
several factors. In this paper, we summarize the niche
and intrinsic factors in regulating SSC self-renewal and
proliferation. GDNF regulates SSC self-renewal through
Ras-ERK1/2, SFC, PI3K/Akt and MEK/ERK-mTOR
signaling pathways. FGF activates MAPK2K1, ERK and
Akt pathways and EGF activates ERK and Akt pathways
to induce SSC proliferation. Wnt ligands regulate SSC
self-renewal and proliferation through both β-catenin
dependent and independent pathways. SCF1 and
CXCL12 are also found to have roles in SSC
maintenance. As for intrinsic factors in SSCs, ETV5,
Bcl6b, Lhx1, ID4 and Nanos2 are regulated by niche
factors. They act as the downstream factors of niche
factors in regulating SSC self-renewal and proliferation.
Transcriptional factors OCT4 and PLZF, as well as
FOXO1 in SSCs can directly regulate SSC self-renewal
and proliferation. Although we have identified the
factors, the detailed mechanism of these factors in
regulating SSC fate determination is largely unknown.
Here, we summarize factors which have roles in SSC
fate determination and hope it will be beneficial for
further study and treatment of male infertility.
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Citation
Histology and Histopathology Vol. 37, nº9 (2022)
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