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The early appearance of asthma and its relationship with gut microbiota: a narrative review

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dc.contributor.authorSuárez Martínez, Clara
dc.contributor.authorSantaella-Pascual, Marina
dc.contributor.authorYagüe Guirao, Genoveva
dc.contributor.authorGarcía-Marcos Álvarez, Luis Vicente
dc.contributor.authorRos Berruezo, Gaspar
dc.contributor.authorMartínez Gracia, Carmen
dc.contributor.departmentTecnología de Alimentos, Nutrición y Bromatología
dc.contributor.otherFacultad de Veterinaria
dc.date.accessioned2026-01-23T08:30:20Z
dc.date.available2026-01-23T08:30:20Z
dc.date.copyright© 2024 by the authors
dc.date.issued2024-07-19
dc.description.abstractAsthma is, worldwide, the most frequent non-communicable disease affecting both children and adults, with high morbidity and relatively low mortality, compared to other chronic diseases. In recent decades, the prevalence of asthma has increased in the pediatric population, and, in general, the risk of developing asthma and asthma-like symptoms is higher in children during the first years of life. The “gut–lung axis” concept explains how the gut microbiota influences lung immune function, acting both directly, by stimulating the innate immune system, and indirectly, through the metabolites it generates. Thus, the process of intestinal microbial colonization of the newborn is crucial for his/her future health, and the alterations that might generate dysbiosis during the first 100 days of life are most influential in promoting hypersensitivity diseases. That is why this period is termed the “critical window”. This paper reviews the published evidence on the numerous factors that can act by modifying the profile of the intestinal microbiota of the infant, thereby promoting or inhibiting the risk of asthma later in life. The following factors are specifically addressed in depth here: diet during pregnancy, maternal adherence to a Mediterranean diet, mode of delivery, exposure to antibiotics, and type of infant feeding during the first three months of life.
dc.formatapplication/pdf
dc.format.extent28
dc.identifier.citationMicroorganisms 2024, 12, 1471
dc.identifier.doihttps://doi.org/10.3390/microorganisms12071471
dc.identifier.eissn2076-2607
dc.identifier.urihttp://hdl.handle.net/10201/191469
dc.languageeng
dc.publisherMDPI
dc.relationThis review was supported by grants from Instituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities, and Fondos FEDER (grant numbers CP14/0046, PIE15/0051, PI16/00422, ARADyAL network RD160006, and PID2019-106693RB-100/AEI/10.13039/501100011033). C.S.-M. was funded by a predoctoral fellowship (FPU MECD 15/05809) awarded by the Ministry of Education and Culture as part of the Government of Spain.
dc.relation.publisherversionhttps://www.mdpi.com/2076-2607/12/7/1471
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAsthma
dc.subjectGut microbiota
dc.subjectGut–lung axis
dc.subject.odsObjetivo 3: Salud
dc.titleThe early appearance of asthma and its relationship with gut microbiota: a narrative review
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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