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Resveratrol can prevent CCl4-induced liver injury by inhibiting Notch signaling pathway

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dc.contributor.authorTanriverdi, Gamze
dc.contributor.authorKaya-Dagistanli, Fatma
dc.contributor.authorAyla, Sule
dc.contributor.authorDemirci, Sibel
dc.contributor.authorEser, Mediha
dc.contributor.authorUnal, Seda
dc.contributor.authorCengiz, Mujgan
dc.contributor.authorOktar, Huseyin
dc.date.accessioned2021-07-28T10:51:06Z
dc.date.available2021-07-28T10:51:06Z
dc.date.issued2016
dc.description.abstractWe investigated whether Notch signaling was increased in an experimental liver fibrosis model and examined the effects of resveratrol on Notch expression. Rats were divided into four groups: the control group, injected with physiological saline; the CCl 4 group; the CCl 4 plus resveratrol group; and the resveratrol group. After treatment, immunostaining was performed to detect Notch1, Notch3, Notch4, transforming growth factor (TGF)-beta, alpha-smooth muscle actin (SMA), glial fibrillary acidic protein (GFAP), and proliferating cell nuclear antigen (PCNA), and TUNEL assays were performed to evaluate apoptosis. Sirius red staining was used to detect fibrosis. Samples were also biochemically evaluated for glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT), lipid peroxidation, and protein oxidation. GSH, GPx, and catalase activities were significantly decreased (p<0.001) in the CCl 4 group. Distinct collagen accumulation was detected around the central vein and portal areas, and numbers of Notch1-, Notch3-, and Notch4-positive cells were significantly increased (p<0.001) in fibrotic areas in the CCl 4 group. Increased expression of Notch proteins in fibrotic areas may support the role of Notch in mediating signaling associated with liver fibrosis through activation of hepatic stellate and progenitor cells. In contrast, resveratrol prevented liver fibrosis by decreasing lipid peroxidation and may be effective for inhibiting Notch signaling.es
dc.formatapplication/pdfes
dc.format.extent16es
dc.identifier.citationHistology and histopathology, Vol.31, nÂş7 (2016)
dc.identifier.doiDOI: 10.14670/HH-11-720
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/111410
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLiver fibrosises
dc.subjectNotch signalinges
dc.subjectResveratroles
dc.subjectLiver regenerationes
dc.subjectHepatotoxicityes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleResveratrol can prevent CCl4-induced liver injury by inhibiting Notch signaling pathwayes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.31, nÂş7 (2016)