Publication: Extracellular matrix in renal cell carcinomas
Authors
Lohi, J. ; Leivo, I. ; Oivula, J. ; Lehto, V.P. ; Virtanen, I.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Extracellular matrix (ECM) may be divided
into interstitial matrix and the basement membrane
(BM). ECM influences a variety of epithelial cell
behaviours, including proliferation, differentiation, and
morphogenesis, maybe most widely studied in kidney
morphogenesis. In carcinomas, including renal cell
carcinomas (RCCs), these properties and interactions of
cells with interstitial matrix and BM are disturbed. As a
carcinoma with a tendency to spread to distant sites,
RCC is an interesting target for the study of epithelialstromal
interactions. Among interstitial collagens, type
V1 collagen appears to be widely distributed in RCCs.
Also EDA-fibronectin (EDA-Fn) as well as tenascin-C
(Tn) are important stromal components especially in
poorly differentiated carcinomas. BMs of RCC islets and
those of tumor blood vessel endothelia may merge in
poorly differentiated carcinomas. As a dynamic
component of BMs, laminins (Ln) are important in
kidney development and RCC progression. Type IV
collagen and nidogen, other components of BMs in
RCCs, are produced by stromal as well as epithelial
cells. ECM proteins may function in RCC progression
by binding and regulating the activity of growth factors
e.g. transforming growth factor B1 and basic fibroblast growth factor. Also the expression of cell surface
receptors for ECM is disturbed in RCCs. At least a,
integrin (Int) and CD44 emerge in renal epithelial cells
during malignant transformation. Papillary renal
neoplasms differ from RCCs by cell adhesion receptor
expression and BM composition as well as by ECM
avascularity and capacity to bind growth factors, thus
suggesting a distinct property for this renal tumor.
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