Publication: Density of epidermal Langerhans cells in psoriasis patients treated with an aromatic retinoid, RO 10 9359. An immunoperoxidase study using anti...
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Date
1986
Authors
Guzman de Fleury, M. ; Tapia, F.J. ; Soto, J. ; Ghersi, N. ; Convit, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Immunocytochemical techniques using
antibodies to the specific T6 and Ia (Major
Histocompability Complex, class 11, human HLA-Dr)
antigens were used to determine the densities of epidermal
Langerhans cells (LC) in psoriasis patients treated with the
aromatic retinoid RO 10-9359. Fourteen patients were
treated with the aromatic retinoid and were skin biopsied
before, during and after therapy.
Two psoriasis patients receiving PUVA (systemic
8-metoxypsoralen + UVA irradiation) were included in the
study. The results showed an increase in LC numbers during
aromatic retinoid administration, which coincided with an
improvement in the clinical severity of the lesions. At the
end of retinoid administration the LC numbers were similar
to those found in the initial psoriatic plaques. The density
of la + LC, in comparison with T6 + LC in the epidermis
of psoriatic plaques were significantly different. Dendritic
and non-dendritic Ia+. cells were also observed in the
dermis of the plaques. Unlike aromatic retinoid treated
patients, PUVA treated patients showed a decrease of both
T6+ and Ia + epidermal LC by the middle of therapy, a
total absence of immunoreaction by the end of therapy,
and a return to normal skin values a few weeks after
treatment. This immunocytochemical study helps in
distinguishing between dendritic and other possible Iaexpressing
cells from the infiltrate that may penetrate the
epithelium.
These results do not conclusively demonstrate the role
of LC in the pathogenesis of psoriasis. Other factors, such
Offprintrequests to: Dr. Felix J. Tapia, Laboratorio de Biologia
Molecular, lnstituto de Biomedicina, Apartado 4043, Caracas
101 OA, Venezuela
" Deceased December 1983
as the interrelationship with other immune response cell
types and alterations in the lymphokine cascade may be
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