Publication: Short-term behavior of different polymer structure
lightweight meshes used to repair abdominal wall
defects
Authors
Pascual, G. ; Hernández-Gascón, B. ; Sotomayor, S. ; Peña, E. ; Calvo, B. ; Buján, J. ; Bellón, J.M.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background. While lightweight (LW)
polypropylene (PP) meshes are been used for hernia
repair, new prosthetic meshes also of low-density and
with large pores have recently been introduced composed
of other polymer materials. This study compares the
behavior in the short-term of two macroporous LW
prosthetic materials, PP and non-expanded PTFE.
Methods. Partial defects were created in the lateral
wall of the abdomen in New Zealand White rabbits and
then repaired using a LW PP mesh or a new monofile,
LW PTFE mesh. At 14 days postimplant, shrinkage and
tissue incorporation, gene and protein expression of neocollagens
(qRT-PCR/immunofluorescence), macrophage
response (immunohistochemistry) and biomechanical
strength were determined.
Results. Both meshes induced good host tissue
ingrowth, yet the macrophage response was significantly
greater for the PTFE implants (p<0.05). Collagen 1/3
mRNA expression was greater for the PP mesh but
differences lacked significance. Similar patterns of
collagen I and III protein expression were observed in
the neoformed tissue infiltrating the two meshes. After
14 days of implant, tensile strengths were also similar,
while elastic modulus values were higher for the PTFE
mesh (p<0.05).
Conclusions. In the short term, host collagen
deposition and biomechanical performance seemed
unaffected by the polymer structure of the implanted
mesh. In contrast, the inflammatory response to mesh
implant produced at this early time point was more
intense for the PTFE.
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Citation
Histology and histopathology, Vol. 28, n.º 5 (2013)
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