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Transforming growth factor -a expression in rat experimental hepatocarcinogenesis

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dc.contributor.authorPérez-Tomás, R.es
dc.contributor.authorMayol, X.es
dc.contributor.authorCulleré, X.
dc.contributor.authorDíaz Ruiz, C.
dc.contributor.authorDomingo, J.
dc.date.accessioned2011-02-01T08:47:19Z
dc.date.available2011-02-01T08:47:19Z
dc.date.issued1992
dc.description.abstractGrowth factors in general and transforming growth factor-a in particular have been related to cell proliferation and cell differentiation. This study was designed to clarify the distribution pattem of TGF-a in chemically-induced hepatocarcinogenesis. Sprague- Dawley rats were subjected to different non-intensive or intensive carcinogenic treatments using diethylnitrosamine (DEN) as carcinogen and ethinyl estradiol (EE) as promoter. The livers were fixed in 2% paraformaldehyde, dehydrated in a series of ethanol solutions, embedded in paraffin and sectioned. In the preneoplastic lesions no TGF-a immunoreactive cells were identified, but in some hepatic tumours cell immunostained with TGF-a antibody were observed. These results suggest that the cells capable of expressing TGF-a constitutively may be involved in neoplastic development in vivo.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18324
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHepatocarcinogenesises
dc.subjectTumour promotiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleTransforming growth factor -a expression in rat experimental hepatocarcinogenesises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 7, nº 3 (1992)