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Smoothelin and WT-1 expression in glomus tumors and glomuvenous malformations

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dc.contributor.authorAneiros Fernandez, Jose
dc.contributor.authorRetamero, Juan Antonio
dc.contributor.authorHusein ElAhmed, Husein
dc.contributor.authorCarriel, Víctor
dc.contributor.authorRuiz Villaverde, Ricardo
dc.contributor.authorO’Valle, Francisco
dc.contributor.authorAneiros Cachaza, Jose
dc.date.accessioned2022-02-04T09:05:32Z
dc.date.available2022-02-04T09:05:32Z
dc.date.issued2017
dc.description.abstractBackground: Smoothelin is a specific marker for smooth muscle cells with contractile capacity which has not been widely studied in glomus lesions. In the same way, the expression for Wilms tumor 1 (WT1) has only been studied occasionally in the endothelial cells of glomovenous malformations and in the glomus cells of glomus tumours. Objective: We studied the significance of immunohistochemical expression of smoothelin and WT1 in 25 glomus lesions. Methods: We assessed 9 cases of solid glomus tumors (SGT), 8 cases of glomus tumors with vascular ectasia (VEGT), 2 cases of glomangiomyomas (GMM) and 6 cases of glomuvenous malformation (GM). Immunohistochemistry was performed, evaluating the expression of WT1, smoothelin, smooth muscle actin (SMA), smooth muscle myosin (SMM), h-caldesmon and desmin. Results: Glomic cells showed cytoplasmic positivity for smoothelin, and WT1 expression was present in all studied cases. SGT showed WT1 positivity in all endothelia. However, in regarding VEGT and GMM, WT1 endothelial expression was positive in some areas, but not in others. GM did not show endothelial cell positivity for WT1. Conclusions: Smoothelin expression in glomic cells indicates that they are contractile smooth muscle cells, and thus its role in routine diagnosis should be considered. The absence of WT1 expression in the endothelium of the vascular structures of the GM is a differential characteristic between SGT, VEGT and GMM.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology, Vol.32, nº2, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-782
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/116745
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectWT-1es
dc.subjectSmoothelines
dc.subjectGlomus tumorses
dc.subjectGlomuvenous malformationes
dc.subjectImmunohistochemistryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleSmoothelin and WT-1 expression in glomus tumors and glomuvenous malformationses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nº2 (2017)