Publication: Nestin structure and predicted function in cellular cytoskeletal organisation
Authors
Michalczyk, K. ; Ziman, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Nestin is an intermediate filament protein
expressed in dividing cells during the early stages of
development in the CNS, PNS and in myogenic and
other tissues. Upon differentiation, nestin becomes
downregulated and is replaced by tissue-specific
intermediate filament proteins. Interestingly, nestin
expression is reinduced in the adult during pathological
situations, such as the formation of the glial scar after
CNS injury and during regeneration of injured muscle
tissue. Although it is utilised as a marker of proliferating
and migrating cells very little is known about its
functions or regulation. In depth studies on the
distribution and expression of nestin in mitotically active
cells indicate a complex role in regulation of the
assembly and disassembly of intermediate filaments
which together with other structural proteins, participate
in remodeling of the cell. The role of nestin in dynamic
cells, particularly structural organisation of the cell,
appears strictly regulated by phosphorylation, especially
its integration into heterogeneous intermediate filaments
together with vimentin or a-internexin.
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