Publication: Adrenomedullin expression in pituitary adenomas and nontumoral adenohypophyses
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Date
2008
Authors
Lombardero, M. ; Kovacs, K. ; Horvath, E. ; Scheithauer, B.W. ; Rotondo, F. ; Salehi. F ; Lloyd, R.V.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Summary. Adrenomedullin (ADM) is a novel peptide
originally identified in extracts of human
pheochromocytoma. It is produced by several tissues,
including the pituitary gland. The presence of ADM has
been immunohistochemically demonstrated in
pathologic pituitary glands, but no systematic study of
ADM expression in human pituitary adenomas has been
reported. Thus, we investigated ADM immunoexpression
in 88 various hormone-secreting and
clinically nonfunctioning pituitary adenoma types as
well as 30 nontumoral adenohypophyses. Furthermore,
ADM immunoreactivity was assessed on a 0 to +3 scale
in all samples. We found strong immunoreativity for
ADM in normal gonadotrophs also expressing FSH and
LH whereas in the other adenohypophysial cell types
expression of ADM was mild. Results showed that
normal adenohypophyses were strongly immunopositive
for ADM (2.18±0.11). Our findings demonstrate that
ADM expression in the anterior pituitary is diminished
in tumors as compared to the normal gland. The
physiologic function of ADM is unknown, but it could
act as a paracrine or autocrine factor in the
adenohypophysis.
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