Publication:
The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods

Simple item page
dc.contributor.authorMorales, Eva
dc.contributor.authorAlcantara-Lopez, Maria V.
dc.contributor.authorCabezas-Herrera, Juan
dc.contributor.authorHernandez-Caselles, Trinidad
dc.contributor.authorJimenez-Guerrero, Pedro
dc.contributor.authorLarqué, Elvira
dc.contributor.authorLopez-Soler, Concepción
dc.contributor.authorMartinez-Gracia, Carmen
dc.contributor.authorMartinez-Torres, Antonela
dc.contributor.authorMendiola, Jaime
dc.contributor.authorNieto-Díaz, Aníbal
dc.contributor.authorPerez-Fernandez, Virginia
dc.contributor.authorPrieto-Sánchez, M. Teresa
dc.contributor.authorSalvador-Garcia, Carme
dc.contributor.authorSanchez-Solis, Manuel
dc.contributor.authorSola-Martinez, Rosa A.
dc.contributor.authorTorres-Cantero, Alberto
dc.contributor.authorYagüe-Guirao, Genoveva
dc.contributor.authorZornoza-Moreno, Matilde
dc.contributor.authorGarcía-Marcos, Luis
dc.contributor.authorSantaella-Pascual, Marina
dc.contributor.authorDiego Puente, Teresa de
dc.contributor.authorMartín-Orozco Santiago, María Elena
dc.contributor.authorNoguera Velasco, José Antonio
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-01-31T08:27:21Z
dc.date.available2024-01-31T08:27:21Z
dc.date.issued2022
dc.description.abstractBackground: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests. Objectives: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility. Population: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19–22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the “Virgen de la Arrixaca” University Clinical Hospital over a 36-month period, from March 2015 to April 2018. Design: Prospective, population-based, maternal-child, birth cohort study. Methods: Questionnaires on exposures and outcome variables were administered to mothers at 20–24 gestation week; 32–36 gestation week; and delivery. Children were surveyed at birth, 3 and 18 months of age and currently at 5 years. Furthermore, physical examinations were performed; and different measurements and biological samples were obtained at these time points. Preliminary results: Among the 1350 women invited to participate, 738 (54%) were finally enrolled in the study and 720 of their children were eligible at birth. The adherence was high with 612 children (83%) attending the 3 months’ visit and 532 children (72%) attending the 18 months’ visit. Conclusion: The NELA cohort will add original and unique knowledge to the developmental origins of asthma.en
dc.formatapplication/pdfes
dc.identifier.citationPaediatr Perinat Epidemiol. 2022 Mar 36(2):310-324.
dc.identifier.doihttps://doi.org/10.1111/ppe.12826
dc.identifier.urihttp://hdl.handle.net/10201/138240
dc.languageenges
dc.relationInstituto de Salud Carlos III, Spanish Ministry of Science, Innovation and Universities (Grants: MS14/00046; CP14/00046; PIE15/00051; PI16/00422; FI17/00086; PI19/00863; FPU18/00545), Fondos FEDER, Fundación Séneca, Agencia de Ciencia y Tecnología Región de Murcia (Grant: 20877/PI/18).es
dc.rightsAttribution-NonCommercial-NoDerivates 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAllergyen
dc.subjectAsthmaen
dc.subjectDieten
dc.subjectMother-child cohorten
dc.subjectWheezingen
dc.titleThe Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methodses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublication2d5dac0f-c6c6-485b-97bf-c679f4940e3d
relation.isAuthorOfPublicationb8be181a-7224-475a-8427-543751ef593c
relation.isAuthorOfPublication24de46e8-df34-4c71-a701-2a30b079b958
relation.isAuthorOfPublicationf3810358-f28e-4db9-88fb-457b1c3f4a1f
relation.isAuthorOfPublication.latestForDiscovery2d5dac0f-c6c6-485b-97bf-c679f4940e3d
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
73- Morales- PPE 2022.pdf
Size:
720.72 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos