Publication: Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor
Authors
López-Sánchez, N. ; Frade, J.M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Although traditionally little attention has
been paid to the interplay between neurotrophins and the
cell cycle, a number of recent findings suggest an
important role for these growth factors in the regulation
of this aspect of the cellular physiology.
In this article, we review the evidence from a
number of studies that neurotrophins can influence cell
cycle progression or mitotic cycle arrest both in the
nervous system as well as in other cell types. The
contrary response of different cells to neurotrophins in
terms of cell cycle regulation derives in part from the
fact that these factors use two different receptor types to
transmit their signals: members of the Trk family and the
p75 neurotrophin receptor (p75NTR). With this in mind,
we outline the current state of our knowledge regarding
the molecular basis underlying the control of cell cycle
progression by neurotrophins. We focus our interest on
the receptors that transduce these signals and, in
particular, the striking finding that p75NTR interacts with
proteins that can promote mitotic cycle arrest. Finally,
we discuss the mechanisms of cell death mediated by
p75NTR in the context of cell cycle regulation.
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