Publication: Characterisation of cytotrophoblastic-like cells present in subinvolutioned placental sites of the bitch
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Date
1998
Authors
Fernandez, P.E. ; Portiansky, E.L. ; Barbeito, C.G. ; Gimeno, E.J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This paper describes an approach to study the
cells present in the subinvolution of placental sites
(SIPS), a pathological post partum condition of the bitch
that causes persistent hemorrhage of the genital tract.
The expression of intermediate filament proteins was
examined to determine the fetal or maternal origin of the
cytotrophoblastic-like cells found in this entity. Lectin
binding on tissue sections were also studied to
characterise cellular glycoconjugates. Image processing
and morphometrical analysis of the histological images
were done. The results revealed that the cells observed in
bitches with SIPS expressed pancytokeratins but neither
vimentin nor desmin, in coincidence with normal
cytotrophoblasts. The lectin binding pattern of both
types of cells was similar, with the only exception of
Arachis hypogaea agglutinin (PNA) and Triticum
vulgaris agglutinin (WGA). These observations, in
addition to the non statistically significant differences
between morphometrical characteristics of cytotrophoblastic
and cytotrophoblastic-like cells in SIPS, might
suggest the fetal origin of the latter cells which could
play a role in the pathogenesis of this entity.
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