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Effect of pine bark extract and its phenolic compounds on selected pathogenic and probiotic bacterial strains

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dc.contributor.authorSánchez Moya, Teresa
dc.contributor.authorLópez Nicolás, Rubén
dc.contributor.authorPeso Echarri, Patricia
dc.contributor.authorGonzález-Bermúdez, Carlos A.
dc.contributor.authorFrontela-Saseta, Carmen
dc.contributor.departmentTecnología de Alimentos, Nutrición y Bromatología
dc.date.accessioned2026-01-08T10:09:19Z
dc.date.available2026-01-08T10:09:19Z
dc.date.copyright© 2024 Sánchez-Moya, López-Nicolás, Peso- Echarri, González-Bermúdez and Frontela- Saseta.
dc.date.issued2024-03-27
dc.description.abstractIntroduction: Inflammatory bowel disease (IBD) comprises a heterogeneous group of chronic diseases as ulcerative colitis (UC) and Crohn’s disease (CD). IBD is the result of a dysregulation of intestinal homeostasis with a host’s loss of tolerance toward normal enteric microflora. Plant-based extracts as phenolic compounds can play a role by modulating the intestinal inflammation response. Methods: The in vitro antimicrobial activity of French maritime pine bark extract (PBE) and its phenolic constituents has been investigated in this study. Furthermore, the ability of PBE and phenolic compounds (caffeic acid, chlorogenic acid, ferulic acid, gallic acid and taxifolin) to modulate the microbiota has been assessed. Results: Phenolic compounds and PBE showed a great inhibitory effect on the pathogens growth at the highest concentration assessed (1.25 mg/mL). The growth of E. sakazakii and E. faecalis were affected by the effect of caffeic acid and ferulic acid. Taxifolin showed a very strong activity against Listeria sp. (with a reduction ~98%). Gallic acid revealed antibacterial effect on S. aureus at different concentrations. The inhibitory effect of PBE was highly significant on the growth of E. coli O157:H7. PBE, caffeic acid and chlorogenic acid seem to provide the greatest beneficial effect on the probiotic bacteria. However, the highest concentrations of taxifolin may have impaired the growth of beneficial microbiota. Conclusion: Present findings could be of interest for considering PBE and/or its phenolic constituents as protectors against gastrointestinal disturbances which lead to ulcerative colitis and Crohn’s disease.
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dc.identifier.citationFront. Nutr. 11:1381125.
dc.identifier.doihttps://doi.org/10.3389/fnut.2024.1381125
dc.identifier.eissn2296-861X
dc.identifier.urihttp://hdl.handle.net/10201/184709
dc.languageeng
dc.publisherFrontiers
dc.relationMinisterio de Economía y Competitividad (Spain) for the project reference AGL2016-78125-R.
dc.relation.publisherversionhttps://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1381125/full
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectInflammatory bowel disease
dc.subjectAntimicrobial activity
dc.subjectPathogenic bacteria
dc.subjectProbiotics
dc.subjectPine bark extract
dc.subjectPhenolic compounds
dc.subject.odsObjetivo 3: Salud
dc.titleEffect of pine bark extract and its phenolic compounds on selected pathogenic and probiotic bacterial strains
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
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relation.isAuthorOfPublication6d5e0bf5-ef34-4006-afba-2462c3cb77f4
relation.isAuthorOfPublicationc1956eb9-aa8f-4744-97a3-d316e752a940
relation.isAuthorOfPublication.latestForDiscoverye6769261-f6c8-4e39-bc7a-12783087132a
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